Longitudinal assessment of neuropathy in type 1 diabetes using novel ophthalmic markers (LANDMark): Study design and baseline characteristics

Nicola Pritchard, Katie Edwards, Cirous Dehghani, Hassan Fadavi, Maria Jeziorska, Andrew Marshall, Ioannis N. Petropoulos, Georgios Ponirakis, Anthony W. Russell, Geoff P. Sampson, Ayda M. Shahidi, Sangeetha Srinivasan, Mitra Tavakoli, Dimitrios Vagenas, Rayaz A. Malik, Nathan Efron

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    Abstract

    Aims: Corneal nerve morphology and corneal sensation threshold have recently been explored as potential surrogate markers for the evaluation of diabetic neuropathy. We present the baseline findings of the 'Longitudinal Assessment of Neuropathy in type 1 Diabetes using novel ophthalmic Markers'(LANDMark) study. Methods: The LANDMark study is a 4-year, two-site, natural history study of three participant groups: type 1 diabetes with neuropathy (T1W), type 1 diabetes without neuropathy (T1WO) and control participants without diabetes or neuropathy. All participants undergo a detailed annual assessment of neuropathy including corneal nerve parameters measured using corneal confocal microscopy and corneal sensitivity measured using non-contact corneal aesthesiometry. Results: 76 T1W, 166 T1WO and 154 control participants were enrolled into the study. Corneal sensation threshold was significantly higher (i.e., sensitivity was lower) in T1W (1.0±1.1mbars) than T1WO (0.7±0.7mbars) and controls (0.6±0.4mbars) (p
    Original languageEnglish
    Pages (from-to)248-256
    Number of pages8
    JournalDiabetes Research and Clinical Practice
    Volume104
    Issue number2
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Corneal confocal microscopy
    • Diabetic neuropathy
    • LANDMark study
    • Longitudinal trial
    • Non-contact corneal aesthesiometry

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