Longitudinal cerebral diffusion changes reflect progressive decline of language and cognition

Lars Frings, Katharina Dressel, Stefanie Abel, Irina Mader, Volkmar Glauche, Cornelius Weiller, Michael Hüll

    Research output: Contribution to journalArticlepeer-review


    Language deficits are regularly found in cortical neurodegenerative diseases. The progression of language deficits shows a considerable inter-individual variability even within one diagnostic group. We aimed at detecting patterns of altered diffusion as well as atrophy of cerebral gray and white matter which underlie ongoing language-related deterioration in patients with cortical neurodegenerative diseases. Diffusion tensor imaging and T1-weighted MRI data of 26 patients with clinically diagnosed neurodegenerative disorders were acquired at baseline and 14 months later in this prospective study. Language functions were assessed with a confrontation naming test and the Token Test. Diffusion and voxel-based morphometric measures were calculated and correlates of language performance were evaluated. Across all patients, the naming impairment was related to diffusion (false discovery rate-corrected P
    Original languageEnglish
    Pages (from-to)395-401
    Number of pages6
    JournalPsychiatry Research - Neuroimaging
    Issue number3
    Publication statusPublished - 30 Dec 2013


    • Cognition
    • Dementia
    • Diffusion tensor imaging
    • Language
    • Voxel-based morphometry


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