Longitudinal cerebral diffusion changes reflect progressive decline of language and cognition

Lars Frings; Katharina Dressel; Stefanie Abel; Irina Mader; Volkmar Glauche; Cornelius Weiller; Michael Hüll

doi:10.1016/j.pscychresns.2013.08.003

Longitudinal cerebral diffusion changes reflect progressive decline of language and cognition

Lars Frings, Katharina Dressel, Stefanie Abel, Irina Mader, Volkmar Glauche, Cornelius Weiller, Michael Hüll

Research output: Contribution to journal › Article › peer-review

Abstract

Language deficits are regularly found in cortical neurodegenerative diseases. The progression of language deficits shows a considerable inter-individual variability even within one diagnostic group. We aimed at detecting patterns of altered diffusion as well as atrophy of cerebral gray and white matter which underlie ongoing language-related deterioration in patients with cortical neurodegenerative diseases. Diffusion tensor imaging and T1-weighted MRI data of 26 patients with clinically diagnosed neurodegenerative disorders were acquired at baseline and 14 months later in this prospective study. Language functions were assessed with a confrontation naming test and the Token Test. Diffusion and voxel-based morphometric measures were calculated and correlates of language performance were evaluated. Across all patients, the naming impairment was related to diffusion (false discovery rate-corrected P

Original language	English
Pages (from-to)	395-401
Number of pages	6
Journal	Psychiatry Research - Neuroimaging
Volume	214
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2013.08.003
Publication status	Published - 30 Dec 2013

Keywords

Cognition
Dementia
Diffusion tensor imaging
Language
Voxel-based morphometry

Access to Document

10.1016/j.pscychresns.2013.08.003

Cite this

@article{a269adcb0f094e0eb2d6cf6b93b76189,

title = "Longitudinal cerebral diffusion changes reflect progressive decline of language and cognition",

abstract = "Language deficits are regularly found in cortical neurodegenerative diseases. The progression of language deficits shows a considerable inter-individual variability even within one diagnostic group. We aimed at detecting patterns of altered diffusion as well as atrophy of cerebral gray and white matter which underlie ongoing language-related deterioration in patients with cortical neurodegenerative diseases. Diffusion tensor imaging and T1-weighted MRI data of 26 patients with clinically diagnosed neurodegenerative disorders were acquired at baseline and 14 months later in this prospective study. Language functions were assessed with a confrontation naming test and the Token Test. Diffusion and voxel-based morphometric measures were calculated and correlates of language performance were evaluated. Across all patients, the naming impairment was related to diffusion (false discovery rate-corrected P",

keywords = "Cognition, Dementia, Diffusion tensor imaging, Language, Voxel-based morphometry",

author = "Lars Frings and Katharina Dressel and Stefanie Abel and Irina Mader and Volkmar Glauche and Cornelius Weiller and Michael H{\"u}ll",

year = "2013",

month = dec,

day = "30",

doi = "10.1016/j.pscychresns.2013.08.003",

language = "English",

volume = "214",

pages = "395--401",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Longitudinal cerebral diffusion changes reflect progressive decline of language and cognition

AU - Frings, Lars

AU - Dressel, Katharina

AU - Abel, Stefanie

AU - Mader, Irina

AU - Glauche, Volkmar

AU - Weiller, Cornelius

AU - Hüll, Michael

PY - 2013/12/30

Y1 - 2013/12/30

N2 - Language deficits are regularly found in cortical neurodegenerative diseases. The progression of language deficits shows a considerable inter-individual variability even within one diagnostic group. We aimed at detecting patterns of altered diffusion as well as atrophy of cerebral gray and white matter which underlie ongoing language-related deterioration in patients with cortical neurodegenerative diseases. Diffusion tensor imaging and T1-weighted MRI data of 26 patients with clinically diagnosed neurodegenerative disorders were acquired at baseline and 14 months later in this prospective study. Language functions were assessed with a confrontation naming test and the Token Test. Diffusion and voxel-based morphometric measures were calculated and correlates of language performance were evaluated. Across all patients, the naming impairment was related to diffusion (false discovery rate-corrected P

AB - Language deficits are regularly found in cortical neurodegenerative diseases. The progression of language deficits shows a considerable inter-individual variability even within one diagnostic group. We aimed at detecting patterns of altered diffusion as well as atrophy of cerebral gray and white matter which underlie ongoing language-related deterioration in patients with cortical neurodegenerative diseases. Diffusion tensor imaging and T1-weighted MRI data of 26 patients with clinically diagnosed neurodegenerative disorders were acquired at baseline and 14 months later in this prospective study. Language functions were assessed with a confrontation naming test and the Token Test. Diffusion and voxel-based morphometric measures were calculated and correlates of language performance were evaluated. Across all patients, the naming impairment was related to diffusion (false discovery rate-corrected P

KW - Cognition

KW - Dementia

KW - Diffusion tensor imaging

KW - Language

KW - Voxel-based morphometry

U2 - 10.1016/j.pscychresns.2013.08.003

DO - 10.1016/j.pscychresns.2013.08.003

M3 - Article

C2 - 24144508

SN - 0925-4927

VL - 214

SP - 395

EP - 401

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

IS - 3

ER -

Longitudinal cerebral diffusion changes reflect progressive decline of language and cognition

Abstract

Keywords

Access to Document

Fingerprint

Cite this