Longitudinal change in mammographic density and association with breast cancer risk: A case-control study

Chew Ting; Susan M. Astley; Julie Morris; Paula Stavrinos; Mary Wilson; Nicky Barr; Caroline Boggis; Jamie C. Sergeant

doi:10.1007/978-3-642-31271-7_27

Longitudinal change in mammographic density and association with breast cancer risk: A case-control study

Chew Ting, Susan M. Astley, Julie Morris, Paula Stavrinos, Mary Wilson, Nicky Barr, Caroline Boggis, Jamie C. Sergeant

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Abstract

High mammographic breast density is associated with increased risk of breast cancer, but how risk varies with longitudinal change in density is less clear. To investigate, a case-control study of 30 women with screen-detected cancer and 30 women with a normal mammogram, all with two previous normal mammograms, was conducted. Percentage density for all mammograms was estimated with the thresholding software Cumulus. Mean density at first screen was not significantly different in cases and controls in contralateral (36.5 vs. 32.6, p = 0.23) or ipsilateral (36.0 vs. 32.9 p = 0.37) breasts, but mean reduction in density from first to third screen was significantly different in both contralateral (10.7 vs. 5.1, p = 0.02) and ipsilateral (11.7 vs. 6.2, p = 0.04) breasts. Using logistic regression, and controlling for age and HRT use, breast cancer risk was found to be associated with change in density from first to third screen. © 2012 Springer-Verlag Berlin Heidelberg.

Original language	English
Title of host publication	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)\|Lect. Notes Comput. Sci.
Place of Publication	Berlin Heidelberg
Publisher	Springer Nature
Pages	205-211
Number of pages	6
Volume	7361
ISBN (Print)	9783642312700
DOIs	https://doi.org/10.1007/978-3-642-31271-7_27
Publication status	Published - 2012
Event	11th International Workshop on Breast Imaging, IWDM 2012 - Philadelphia, PA Duration: 1 Jul 2012 → …

Conference

Conference	11th International Workshop on Breast Imaging, IWDM 2012
City	Philadelphia, PA
Period	1/07/12 → …

Keywords

breast cancer risk
case-control study
Cumulus
Mammographic density

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-642-31271-7_27

Cite this

Ting, C., Astley, S. M., Morris, J., Stavrinos, P., Wilson, M., Barr, N., Boggis, C., & Sergeant, J. C. (2012). Longitudinal change in mammographic density and association with breast cancer risk: A case-control study. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci. (Vol. 7361, pp. 205-211). Springer Nature. https://doi.org/10.1007/978-3-642-31271-7_27

Ting, Chew ; Astley, Susan M. ; Morris, Julie et al. / Longitudinal change in mammographic density and association with breast cancer risk: A case-control study. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. Vol. 7361 Berlin Heidelberg : Springer Nature, 2012. pp. 205-211

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title = "Longitudinal change in mammographic density and association with breast cancer risk: A case-control study",

abstract = "High mammographic breast density is associated with increased risk of breast cancer, but how risk varies with longitudinal change in density is less clear. To investigate, a case-control study of 30 women with screen-detected cancer and 30 women with a normal mammogram, all with two previous normal mammograms, was conducted. Percentage density for all mammograms was estimated with the thresholding software Cumulus. Mean density at first screen was not significantly different in cases and controls in contralateral (36.5 vs. 32.6, p = 0.23) or ipsilateral (36.0 vs. 32.9 p = 0.37) breasts, but mean reduction in density from first to third screen was significantly different in both contralateral (10.7 vs. 5.1, p = 0.02) and ipsilateral (11.7 vs. 6.2, p = 0.04) breasts. Using logistic regression, and controlling for age and HRT use, breast cancer risk was found to be associated with change in density from first to third screen. {\textcopyright} 2012 Springer-Verlag Berlin Heidelberg.",

keywords = "breast cancer risk, case-control study, Cumulus, Mammographic density",

author = "Chew Ting and Astley, {Susan M.} and Julie Morris and Paula Stavrinos and Mary Wilson and Nicky Barr and Caroline Boggis and Sergeant, {Jamie C.}",

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doi = "10.1007/978-3-642-31271-7_27",

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Ting, C, Astley, SM, Morris, J, Stavrinos, P, Wilson, M, Barr, N, Boggis, C & Sergeant, JC 2012, Longitudinal change in mammographic density and association with breast cancer risk: A case-control study. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. vol. 7361, Springer Nature, Berlin Heidelberg, pp. 205-211, 11th International Workshop on Breast Imaging, IWDM 2012, Philadelphia, PA, 1/07/12. https://doi.org/10.1007/978-3-642-31271-7_27

Longitudinal change in mammographic density and association with breast cancer risk: A case-control study. / Ting, Chew; Astley, Susan M.; Morris, Julie et al.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. Vol. 7361 Berlin Heidelberg: Springer Nature, 2012. p. 205-211.

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

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AB - High mammographic breast density is associated with increased risk of breast cancer, but how risk varies with longitudinal change in density is less clear. To investigate, a case-control study of 30 women with screen-detected cancer and 30 women with a normal mammogram, all with two previous normal mammograms, was conducted. Percentage density for all mammograms was estimated with the thresholding software Cumulus. Mean density at first screen was not significantly different in cases and controls in contralateral (36.5 vs. 32.6, p = 0.23) or ipsilateral (36.0 vs. 32.9 p = 0.37) breasts, but mean reduction in density from first to third screen was significantly different in both contralateral (10.7 vs. 5.1, p = 0.02) and ipsilateral (11.7 vs. 6.2, p = 0.04) breasts. Using logistic regression, and controlling for age and HRT use, breast cancer risk was found to be associated with change in density from first to third screen. © 2012 Springer-Verlag Berlin Heidelberg.

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ER -

Ting C, Astley SM, Morris J, Stavrinos P, Wilson M, Barr N et al. Longitudinal change in mammographic density and association with breast cancer risk: A case-control study. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. Vol. 7361. Berlin Heidelberg: Springer Nature. 2012. p. 205-211 doi: 10.1007/978-3-642-31271-7_27

Longitudinal change in mammographic density and association with breast cancer risk: A case-control study

Abstract

Conference

Keywords

UN SDGs

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