Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease

Jennifer C. Thompson; Jenny Harris; Andrea C. Sollom; Cheryl L. Stopford; Elizabeth Howard; Julie S. Snowden; David Craufurd

doi:10.1176/appi.neuropsych.11030057

Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease

Jennifer C. Thompson, Jenny Harris, Andrea C. Sollom, Cheryl L. Stopford, Elizabeth Howard, Julie S. Snowden, David Craufurd

Research output: Contribution to journal › Article › peer-review

Abstract

A group of 111 patients with Huntington's disease (HD) underwent a minimum of three annual neuropsychiatric assessments, using the Problem Behaviors Assessment for Huntington's Disease (PBA-HD). Longitudinal prevalence of neuropsychiatric symptoms was notably higher than baseline prevalence, suggesting that previous studies may have underestimated the extent of this clinical problem. Moreover, apathy, irritability, and depression were each associated with distinct longitudinal profiles. Apathy progressed over time and across disease stages. Irritability also increased significantly, but only in early stages of HD. Depression did not increase significantly at any stage of disease. The neuropsychiatric syndrome of apathy appears to be intrinsic to the evolution and progression of HD. © 2012 American Psychiatric Association.

Original language	English
Pages (from-to)	53-60
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	24
Issue number	1
DOIs	https://doi.org/10.1176/appi.neuropsych.11030057
Publication status	Published - 2012

Keywords

Adult
Aged
Behavioral Symptoms/*diagnosis/*epidemiology
Female
Humans
Huntington Disease/*epidemiology
Longitudinal Studies
Male
Mental Disorders/*diagnosis/*epidemiology
Middle Aged
Neuropsychological Tests
Prevalence
Psychiatric Status Rating Scales

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10.1176/appi.neuropsych.11030057

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title = "Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease",

abstract = "A group of 111 patients with Huntington's disease (HD) underwent a minimum of three annual neuropsychiatric assessments, using the Problem Behaviors Assessment for Huntington's Disease (PBA-HD). Longitudinal prevalence of neuropsychiatric symptoms was notably higher than baseline prevalence, suggesting that previous studies may have underestimated the extent of this clinical problem. Moreover, apathy, irritability, and depression were each associated with distinct longitudinal profiles. Apathy progressed over time and across disease stages. Irritability also increased significantly, but only in early stages of HD. Depression did not increase significantly at any stage of disease. The neuropsychiatric syndrome of apathy appears to be intrinsic to the evolution and progression of HD. {\textcopyright} 2012 American Psychiatric Association.",

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author = "Thompson, {Jennifer C.} and Jenny Harris and Sollom, {Andrea C.} and Stopford, {Cheryl L.} and Elizabeth Howard and Snowden, {Julie S.} and David Craufurd",

year = "2012",

doi = "10.1176/appi.neuropsych.11030057",

language = "English",

volume = "24",

pages = "53--60",

journal = "Journal of Neuropsychiatry and Clinical Neurosciences",

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publisher = "American Psychiatric Association",

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T1 - Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease

AU - Thompson, Jennifer C.

AU - Harris, Jenny

AU - Sollom, Andrea C.

AU - Stopford, Cheryl L.

AU - Howard, Elizabeth

AU - Snowden, Julie S.

AU - Craufurd, David

PY - 2012

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N2 - A group of 111 patients with Huntington's disease (HD) underwent a minimum of three annual neuropsychiatric assessments, using the Problem Behaviors Assessment for Huntington's Disease (PBA-HD). Longitudinal prevalence of neuropsychiatric symptoms was notably higher than baseline prevalence, suggesting that previous studies may have underestimated the extent of this clinical problem. Moreover, apathy, irritability, and depression were each associated with distinct longitudinal profiles. Apathy progressed over time and across disease stages. Irritability also increased significantly, but only in early stages of HD. Depression did not increase significantly at any stage of disease. The neuropsychiatric syndrome of apathy appears to be intrinsic to the evolution and progression of HD. © 2012 American Psychiatric Association.

AB - A group of 111 patients with Huntington's disease (HD) underwent a minimum of three annual neuropsychiatric assessments, using the Problem Behaviors Assessment for Huntington's Disease (PBA-HD). Longitudinal prevalence of neuropsychiatric symptoms was notably higher than baseline prevalence, suggesting that previous studies may have underestimated the extent of this clinical problem. Moreover, apathy, irritability, and depression were each associated with distinct longitudinal profiles. Apathy progressed over time and across disease stages. Irritability also increased significantly, but only in early stages of HD. Depression did not increase significantly at any stage of disease. The neuropsychiatric syndrome of apathy appears to be intrinsic to the evolution and progression of HD. © 2012 American Psychiatric Association.

KW - Adult

KW - Aged

KW - Behavioral Symptoms/diagnosis/epidemiology

KW - Female

KW - Humans

KW - Huntington Disease/epidemiology

KW - Longitudinal Studies

KW - Male

KW - Mental Disorders/diagnosis/epidemiology

KW - Middle Aged

KW - Neuropsychological Tests

KW - Prevalence

KW - Psychiatric Status Rating Scales

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SN - 1545-7222

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SP - 53

EP - 60

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

IS - 1

ER -

Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease

Abstract

Keywords

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