Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients

Annika Antonsson; Tim Waterboer; Jan N. Bouwes Bavinck; Damiano Abeni; Maurits de Koning; Sylvie Euvrard; Mariet C W Feltkamp; Adèle C. Green; Catherine A. Harwood; Luigi Naldi; Ingo Nindl; Herbert J. Pfister; Charlotte M. Proby; Wim G. Quint; Eggert Stockfleth; Sönke J. Weissenborn; Michael Pawlita; Rachel E. Neale

doi:10.1016/j.virol.2012.10.037

Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients

Annika Antonsson, Tim Waterboer, Jan N. Bouwes Bavinck, Damiano Abeni, Maurits de Koning, Sylvie Euvrard, Mariet C W Feltkamp, Adèle C. Green, Catherine A. Harwood, Luigi Naldi, Ingo Nindl, Herbert J. Pfister, Charlotte M. Proby, Wim G. Quint, Eggert Stockfleth, Sönke J. Weissenborn, Michael Pawlita, Rachel E. Neale

Research output: Contribution to journal › Article › peer-review

Abstract

Organ transplant recipients (OTR) are at increased risk of cutaneous squamous cell carcinoma, which may be related to reactivation of human papillomavirus (HPV) infections. Measurement of change in HPV antibodies after transplantation would help to explore this hypothesis. We measured antibodies to 34 HPV types on up to six occasions over 18 months in 441 OTRs from five European countries. At baseline (mean 24 days after transplantation), 80% of all OTRs were seropositive to at least one HPV type. The beta HPV genus had the highest seroprevalence (45%). For most HPV genera baseline seroprevalence peaked between 40 and 59 years old. Most OTRs retained their serostatus over time and antibody levels were stable. Seroprevalence in immunosuppressed OTRs is stable in the 18 months immediately after transplantation. Thus there is no short-term evidence that immunosuppression leads to new or reactivated skin infection with HPV sufficient to induce antibodies. © 2012 Elsevier Inc.

Original language	English
Pages (from-to)	91-99
Number of pages	8
Journal	Virology
Volume	436
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2012.10.037
Publication status	Published - 5 Feb 2013

Keywords

Antibody stability
Human papillomavirus
Longitudinal study
Organ transplanted recipients
Serology
Seroprevalence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.virol.2012.10.037

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Antonsson, A., Waterboer, T., Bouwes Bavinck, J. N., Abeni, D., de Koning, M., Euvrard, S., Feltkamp, M. C. W., Green, A. C., Harwood, C. A., Naldi, L., Nindl, I., Pfister, H. J., Proby, C. M., Quint, W. G., Stockfleth, E., Weissenborn, S. J., Pawlita, M., & Neale, R. E. (2013). Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients. Virology, 436(1), 91-99. https://doi.org/10.1016/j.virol.2012.10.037

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title = "Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients",

abstract = "Organ transplant recipients (OTR) are at increased risk of cutaneous squamous cell carcinoma, which may be related to reactivation of human papillomavirus (HPV) infections. Measurement of change in HPV antibodies after transplantation would help to explore this hypothesis. We measured antibodies to 34 HPV types on up to six occasions over 18 months in 441 OTRs from five European countries. At baseline (mean 24 days after transplantation), 80% of all OTRs were seropositive to at least one HPV type. The beta HPV genus had the highest seroprevalence (45%). For most HPV genera baseline seroprevalence peaked between 40 and 59 years old. Most OTRs retained their serostatus over time and antibody levels were stable. Seroprevalence in immunosuppressed OTRs is stable in the 18 months immediately after transplantation. Thus there is no short-term evidence that immunosuppression leads to new or reactivated skin infection with HPV sufficient to induce antibodies. {\textcopyright} 2012 Elsevier Inc.",

keywords = "Antibody stability, Human papillomavirus, Longitudinal study, Organ transplanted recipients, Serology, Seroprevalence",

author = "Annika Antonsson and Tim Waterboer and {Bouwes Bavinck}, {Jan N.} and Damiano Abeni and {de Koning}, Maurits and Sylvie Euvrard and Feltkamp, {Mariet C W} and Green, {Ad{\`e}le C.} and Harwood, {Catherine A.} and Luigi Naldi and Ingo Nindl and Pfister, {Herbert J.} and Proby, {Charlotte M.} and Quint, {Wim G.} and Eggert Stockfleth and Weissenborn, {S{\"o}nke J.} and Michael Pawlita and Neale, {Rachel E.}",

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doi = "10.1016/j.virol.2012.10.037",

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Antonsson, A, Waterboer, T, Bouwes Bavinck, JN, Abeni, D, de Koning, M, Euvrard, S, Feltkamp, MCW, Green, AC, Harwood, CA, Naldi, L, Nindl, I, Pfister, HJ, Proby, CM, Quint, WG, Stockfleth, E, Weissenborn, SJ, Pawlita, M & Neale, RE 2013, 'Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients', Virology, vol. 436, no. 1, pp. 91-99. https://doi.org/10.1016/j.virol.2012.10.037

TY - JOUR

T1 - Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients

AU - Antonsson, Annika

AU - Waterboer, Tim

AU - Bouwes Bavinck, Jan N.

AU - Abeni, Damiano

AU - de Koning, Maurits

AU - Euvrard, Sylvie

AU - Feltkamp, Mariet C W

AU - Green, Adèle C.

AU - Harwood, Catherine A.

AU - Naldi, Luigi

AU - Nindl, Ingo

AU - Pfister, Herbert J.

AU - Proby, Charlotte M.

AU - Quint, Wim G.

AU - Stockfleth, Eggert

AU - Weissenborn, Sönke J.

AU - Pawlita, Michael

AU - Neale, Rachel E.

PY - 2013/2/5

Y1 - 2013/2/5

N2 - Organ transplant recipients (OTR) are at increased risk of cutaneous squamous cell carcinoma, which may be related to reactivation of human papillomavirus (HPV) infections. Measurement of change in HPV antibodies after transplantation would help to explore this hypothesis. We measured antibodies to 34 HPV types on up to six occasions over 18 months in 441 OTRs from five European countries. At baseline (mean 24 days after transplantation), 80% of all OTRs were seropositive to at least one HPV type. The beta HPV genus had the highest seroprevalence (45%). For most HPV genera baseline seroprevalence peaked between 40 and 59 years old. Most OTRs retained their serostatus over time and antibody levels were stable. Seroprevalence in immunosuppressed OTRs is stable in the 18 months immediately after transplantation. Thus there is no short-term evidence that immunosuppression leads to new or reactivated skin infection with HPV sufficient to induce antibodies. © 2012 Elsevier Inc.

AB - Organ transplant recipients (OTR) are at increased risk of cutaneous squamous cell carcinoma, which may be related to reactivation of human papillomavirus (HPV) infections. Measurement of change in HPV antibodies after transplantation would help to explore this hypothesis. We measured antibodies to 34 HPV types on up to six occasions over 18 months in 441 OTRs from five European countries. At baseline (mean 24 days after transplantation), 80% of all OTRs were seropositive to at least one HPV type. The beta HPV genus had the highest seroprevalence (45%). For most HPV genera baseline seroprevalence peaked between 40 and 59 years old. Most OTRs retained their serostatus over time and antibody levels were stable. Seroprevalence in immunosuppressed OTRs is stable in the 18 months immediately after transplantation. Thus there is no short-term evidence that immunosuppression leads to new or reactivated skin infection with HPV sufficient to induce antibodies. © 2012 Elsevier Inc.

KW - Antibody stability

KW - Human papillomavirus

KW - Longitudinal study

KW - Organ transplanted recipients

KW - Serology

KW - Seroprevalence

U2 - 10.1016/j.virol.2012.10.037

DO - 10.1016/j.virol.2012.10.037

M3 - Article

C2 - 23174506

SN - 0042-6822

VL - 436

SP - 91

EP - 99

JO - Virology

JF - Virology

IS - 1

ER -

Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients

Abstract

Keywords

UN SDGs

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