Abstract
In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
Original language | English |
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Journal | Br J Cancer |
Volume | 87, 2 |
Publication status | Published - 2002 |
Keywords
- Adenocarcinoma/*enzymology
- Aged
- Aged, 80 and over
- Alkylating Agents/adverse effects/pharmacokinetics
- Cecal Neoplasms/enzymology
- Colon/*enzymology
- Female
- Human
- Intestinal Mucosa/enzymology
- Male
- Middle Age
- Neoplasm Proteins/*analysis
- O(6)-Methylguanine-DNA Methyltransferase/*analysis
- Rectal Neoplasms/*enzymology
- Rectum/*enzymology
- Sigmoid Neoplasms/enzymology
- Support, Non-U.S. Gov't
- Variation (Genetics)