Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

N. P Lees, K. L Harrison, E Hill, C. N Hall, G. P Margison, AC. Povey

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
    Original languageEnglish
    JournalBr J Cancer
    Volume87, 2
    Publication statusPublished - 2002

    Keywords

    • Adenocarcinoma/*enzymology
    • Aged
    • Aged, 80 and over
    • Alkylating Agents/adverse effects/pharmacokinetics
    • Cecal Neoplasms/enzymology
    • Colon/*enzymology
    • Female
    • Human
    • Intestinal Mucosa/enzymology
    • Male
    • Middle Age
    • Neoplasm Proteins/*analysis
    • O(6)-Methylguanine-DNA Methyltransferase/*analysis
    • Rectal Neoplasms/*enzymology
    • Rectum/*enzymology
    • Sigmoid Neoplasms/enzymology
    • Support, Non-U.S. Gov't
    • Variation (Genetics)

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