Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes

Adrian H. Heald; Lars Kärvestedt; Simon G. Anderson; Julie McLaughlin; Anne Knowles; Louise Wong; Valdemar Grill; J. Kennedy Cruickshank; Anne White; J. Martin Gibson; Kerstin Brismar

doi:10.1016/j.amjmed.2005.08.001

Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes

Adrian H. Heald
, Lars Kärvestedt
, Simon G. Anderson
, Julie McLaughlin
, Anne Knowles
, Louise Wong
, Valdemar Grill
, J. Kennedy Cruickshank
, Anne White
, J. Martin Gibson
, Kerstin Brismar

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Insulin-like growth factor (IGF)-I and IGF-II are important in the regulation of metabolism and growth. We previously reported in normoglycemic individuals of normal weight that low circulating IGF-II predicts future weight gain. We subsequently investigated whether such relationships persisted in circumstances of type 2 diabetes. METHODS: In 224 subjects with type 2 diabetes we assessed the association between baseline IGF-II levels and risk of weight gain (>2.0 kg) at the 5-year follow-up. RESULTS: At follow-up, 90 participants (40.2%) gained more than 2.0 kg in body weight. For subjects (body mass index

Original language	English
Pages (from-to)	167-e15
Journal	The American Journal of Medicine
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/j.amjmed.2005.08.001
Publication status	Published - Feb 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

IGF-II
Type 2 diabetes
Weight gain

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10.1016/j.amjmed.2005.08.001

Cite this

Heald, A. H., Kärvestedt, L., Anderson, S. G., McLaughlin, J., Knowles, A., Wong, L., Grill, V., Cruickshank, J. K., White, A., Gibson, J. M., & Brismar, K. (2006). Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes. The American Journal of Medicine, 119(2), 167-e15. https://doi.org/10.1016/j.amjmed.2005.08.001

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title = "Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes",

abstract = "PURPOSE: Insulin-like growth factor (IGF)-I and IGF-II are important in the regulation of metabolism and growth. We previously reported in normoglycemic individuals of normal weight that low circulating IGF-II predicts future weight gain. We subsequently investigated whether such relationships persisted in circumstances of type 2 diabetes. METHODS: In 224 subjects with type 2 diabetes we assessed the association between baseline IGF-II levels and risk of weight gain (>2.0 kg) at the 5-year follow-up. RESULTS: At follow-up, 90 participants (40.2\%) gained more than 2.0 kg in body weight. For subjects (body mass index",

keywords = "IGF-II, Type 2 diabetes, Weight gain",

author = "Heald, \{Adrian H.\} and Lars K{\"a}rvestedt and Anderson, \{Simon G.\} and Julie McLaughlin and Anne Knowles and Louise Wong and Valdemar Grill and Cruickshank, \{J. Kennedy\} and Anne White and Gibson, \{J. Martin\} and Kerstin Brismar",

year = "2006",

month = feb,

doi = "10.1016/j.amjmed.2005.08.001",

language = "English",

volume = "119",

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issn = "1555-7162",

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T1 - Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes

AU - Heald, Adrian H.

AU - Kärvestedt, Lars

AU - Anderson, Simon G.

AU - McLaughlin, Julie

AU - Knowles, Anne

AU - Wong, Louise

AU - Grill, Valdemar

AU - Cruickshank, J. Kennedy

AU - White, Anne

AU - Gibson, J. Martin

AU - Brismar, Kerstin

PY - 2006/2

Y1 - 2006/2

N2 - PURPOSE: Insulin-like growth factor (IGF)-I and IGF-II are important in the regulation of metabolism and growth. We previously reported in normoglycemic individuals of normal weight that low circulating IGF-II predicts future weight gain. We subsequently investigated whether such relationships persisted in circumstances of type 2 diabetes. METHODS: In 224 subjects with type 2 diabetes we assessed the association between baseline IGF-II levels and risk of weight gain (>2.0 kg) at the 5-year follow-up. RESULTS: At follow-up, 90 participants (40.2%) gained more than 2.0 kg in body weight. For subjects (body mass index

AB - PURPOSE: Insulin-like growth factor (IGF)-I and IGF-II are important in the regulation of metabolism and growth. We previously reported in normoglycemic individuals of normal weight that low circulating IGF-II predicts future weight gain. We subsequently investigated whether such relationships persisted in circumstances of type 2 diabetes. METHODS: In 224 subjects with type 2 diabetes we assessed the association between baseline IGF-II levels and risk of weight gain (>2.0 kg) at the 5-year follow-up. RESULTS: At follow-up, 90 participants (40.2%) gained more than 2.0 kg in body weight. For subjects (body mass index

KW - IGF-II

KW - Type 2 diabetes

KW - Weight gain

U2 - 10.1016/j.amjmed.2005.08.001

DO - 10.1016/j.amjmed.2005.08.001

M3 - Article

C2 - 16443426

SN - 1555-7162

VL - 119

SP - 167-e15

JO - The American Journal of Medicine

JF - The American Journal of Medicine

IS - 2

ER -

Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes

Abstract

UN SDGs

Keywords

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