Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response

Allison J. Bancroft, Kathryn J. Else, Richard K. Grencis

Research output: Contribution to journalArticlepeer-review

Abstract

Resistance and susceptibility to the intestinal nematode Trichuris muris has been shown to be dependent upon the induction of T helper type 2 (T(h)2) or T(h)1 cells, respectively. This study demonstrates that in a normally resistant strain of mouse, i.e. BALB/K which mounts a dominant T(h)2 response, sub-threshold levels of infection (<40 eggs) can survive and become sexually mature adult worms (10-20 adults). The immunological basis of this phenomenon was found to be a dramatically altered polarization of the CD4 response. The T(h)2-response characteristic of this strain of mouse infected with T. muris was shown to be significantly down-regulated as assessed by in vitro cytokine production [interleukin (IL)-4, IL-5 and IL-9]. In contrast, T(h)1 parameters of infection such as in vitro interferon-γ production and the presence of parasite-specific IgG2a were greatly up-regulated in these mice.
Original languageEnglish
Pages (from-to)3113-3118
Number of pages5
JournalEuropean journal of immunology
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 1994

Keywords

  • Cytokine
  • Low-level infection
  • T(h)1/T(h)2
  • Trichuris muris

Fingerprint

Dive into the research topics of 'Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response'. Together they form a unique fingerprint.

Cite this