Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study

Patrick Mcelduff, Bharti Mackness, Paul Durrington, Patrick McElduff, John Yarnell, Naheed Azam, Michael Watt, Michael Mackness

    Research output: Contribution to journalArticlepeer-review


    Background - The hypothesis that paraoxonase (PON1) has a role in preventing atherosclerosis is based on experimental, transgenic, and case-control studies but has not previously been tested prospectively. Methods and Results - The Caerphilly Prospective Study is a cohort study of men aged 49 to 65 years observed for coronary heart disease (CHD) events (fatal and nonfatal myocardial infarction) over a mean period of 15 years. Serum PON1 activity toward paraoxon was measured in 1353 participants. PON1 activity was 20% lower in the 163 men who had a coronary event (P = 0.039). Men in the highest quintile of PON1 activity had a decreased risk compared with those in the lowest quintile (OR 0.57 [95% CI, 0.33 to 0.96]). The inverse relationship between quintiles of serum PON1 activity and CHD risk was graded, the median change in OR across each quintile being 0.87 (0.77 to 0.98). After adjustment for all other CHD risk factors, including HDL cholesterol, this median value became 0.90 (0.78 to 1.02). PON1 was most predictive of a new CHD event in patients at highest risk by virtue of preexisting CHD (adjusted median OR for each quintile, 0.74 [0.59 to 0.93]; n = 313) or the presence of other risk factors. For the highest tertile of CHD risk (n = 390) calculated by the Framingham equation, adjusted median OR for each quintile was 0.84 (0.66 to 1.05); n = 390. Conclusions - Low serum PON1 activity toward paraoxon is an independent risk factor for coronary events in men at high risk because of preexisting disease or other CHD risk factors.
    Original languageEnglish
    Pages (from-to)2775-2779
    Number of pages4
    Issue number22
    Publication statusPublished - 10 Jun 2003


    • Antioxidants
    • Coronary disease
    • Lipoproteins
    • Myocardial infarction


    Dive into the research topics of 'Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study'. Together they form a unique fingerprint.

    Cite this