Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study

Paul S. McCabe, Stephen Pye, John Mcbeth, David M Lee, Abdelouahid Tajar, Gyorgy Bartfai, Steven Boonen, Roger Bouillon, Felipe Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Ilpo T. Huhtaniemi, Krzysztof Kula, Neil Pendleton, Margus Punab, Dirk Vanderschueren, Frederick C Wu, Terence O'Neill

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Abstract

Background: The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. Methods: Three thousand three hundred sixty nine men aged 40-79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH)D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. Results: Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5%) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH)D (≥36.3 ng/mL), those in the lowest quintile (
Original languageEnglish
JournalB M C Musculoskeletal Disorders
Volume17
Issue number1
DOIs
Publication statusPublished - 16 Jan 2016

Keywords

  • Chronic Widespread Pain
  • Chronic Pain
  • Vitamin D
  • Epidemiology
  • Obesity
  • Depression

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