Lower vitamin D levels are associated with depression among community-dwelling European men

David M. Lee; Abdelouahid Tajar; Terence W. O'Neill; Daryl B. O'Connor; Gyorgy Bartfai; Steven Boonen; Roger Bouillon; Felipe F. Casanueva; Joseph D. Finn; Gianni Forti; Aleksander Giwercman; Thang S. Han; Ilpo T. Huhtaniemi; Krzysztof Kula; Michael E J Lean; Margus Punab; Alan J. Silman; Dirk Vanderschueren; Frederick C W Wu; Neil Pendleton

doi:10.1177/0269881110379287

Lower vitamin D levels are associated with depression among community-dwelling European men

David M. Lee, Abdelouahid Tajar, Terence W. O'Neill, Daryl B. O'Connor, Gyorgy Bartfai, Steven Boonen, Roger Bouillon, Felipe F. Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Michael E J Lean, Margus Punab, Alan J. Silman, Dirk Vanderschueren, Frederick C W Wu, Neil Pendleton

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Abstract

Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n=3369; mean age 60±11) participating in the European Male Ageing Study, and whether any associations were explained by lifestyle and health factors. The Beck Depression Inventory-II (BDI-II) was used to screen for depression, and serum 25(OH)D and PTH levels measured by radioimmunoassay. Univariate analysis revealed that 25(OH)D levels were lower (p

Original language	English
Pages (from-to)	1320-1328
Number of pages	8
Journal	Journal of Psychopharmacology
Volume	25
Issue number	10
DOIs	https://doi.org/10.1177/0269881110379287
Publication status	Published - Oct 2011

Keywords

Ageing
depression
male health
parathyroid hormone
population survey
vitamin D

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Lee, D. M., Tajar, A., O'Neill, T. W., O'Connor, D. B., Bartfai, G., Boonen, S., Bouillon, R., Casanueva, F. F., Finn, J. D., Forti, G., Giwercman, A., Han, T. S., Huhtaniemi, I. T., Kula, K., Lean, M. E. J., Punab, M., Silman, A. J., Vanderschueren, D., Wu, F. C. W., & Pendleton, N. (2011). Lower vitamin D levels are associated with depression among community-dwelling European men. Journal of Psychopharmacology, 25(10), 1320-1328. https://doi.org/10.1177/0269881110379287

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title = "Lower vitamin D levels are associated with depression among community-dwelling European men",

abstract = "Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n=3369; mean age 60±11) participating in the European Male Ageing Study, and whether any associations were explained by lifestyle and health factors. The Beck Depression Inventory-II (BDI-II) was used to screen for depression, and serum 25(OH)D and PTH levels measured by radioimmunoassay. Univariate analysis revealed that 25(OH)D levels were lower (p",

keywords = "Ageing, depression, male health, parathyroid hormone, population survey, vitamin D",

author = "Lee, {David M.} and Abdelouahid Tajar and O'Neill, {Terence W.} and O'Connor, {Daryl B.} and Gyorgy Bartfai and Steven Boonen and Roger Bouillon and Casanueva, {Felipe F.} and Finn, {Joseph D.} and Gianni Forti and Aleksander Giwercman and Han, {Thang S.} and Huhtaniemi, {Ilpo T.} and Krzysztof Kula and Lean, {Michael E J} and Margus Punab and Silman, {Alan J.} and Dirk Vanderschueren and Wu, {Frederick C W} and Neil Pendleton",

year = "2011",

month = oct,

doi = "10.1177/0269881110379287",

language = "English",

volume = "25",

pages = "1320--1328",

journal = "Journal of Psychopharmacology",

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Lee, DM, Tajar, A, O'Neill, TW, O'Connor, DB, Bartfai, G, Boonen, S, Bouillon, R, Casanueva, FF, Finn, JD, Forti, G, Giwercman, A, Han, TS, Huhtaniemi, IT, Kula, K, Lean, MEJ, Punab, M, Silman, AJ, Vanderschueren, D, Wu, FCW & Pendleton, N 2011, 'Lower vitamin D levels are associated with depression among community-dwelling European men', Journal of Psychopharmacology, vol. 25, no. 10, pp. 1320-1328. https://doi.org/10.1177/0269881110379287

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AU - Lee, David M.

AU - Tajar, Abdelouahid

AU - O'Neill, Terence W.

AU - O'Connor, Daryl B.

AU - Bartfai, Gyorgy

AU - Boonen, Steven

AU - Bouillon, Roger

AU - Casanueva, Felipe F.

AU - Finn, Joseph D.

AU - Forti, Gianni

AU - Giwercman, Aleksander

AU - Han, Thang S.

AU - Huhtaniemi, Ilpo T.

AU - Kula, Krzysztof

AU - Lean, Michael E J

AU - Punab, Margus

AU - Silman, Alan J.

AU - Vanderschueren, Dirk

AU - Wu, Frederick C W

AU - Pendleton, Neil

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KW - Ageing

KW - depression

KW - male health

KW - parathyroid hormone

KW - population survey

KW - vitamin D

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DO - 10.1177/0269881110379287

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SN - 1461-7285

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EP - 1328

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

IS - 10

ER -

Lower vitamin D levels are associated with depression among community-dwelling European men

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