Abstract
Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.
Original language | English |
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Pages (from-to) | e1481813 |
Journal | Molecular & cellular oncology |
Volume | 5 |
Issue number | 4 |
Early online date | 1 Aug 2018 |
DOIs | |
Publication status | Published - 2018 |
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre