LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Alba Maiques-diaz, James T. Lynch, Gary J. Spencer, Tim C.p. Somervaille

Research output: Contribution to journalArticlepeer-review


Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.
Original languageEnglish
Pages (from-to)e1481813
JournalMolecular & cellular oncology
Issue number4
Early online date1 Aug 2018
Publication statusPublished - 2018

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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