Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis

Alexander Horsley, A. R. Horsley, P. M. Gustafsson, K. A. Macleod, C. Saunders, A. P. Greening, D. J. Porteous, J. C. Davies, S. Cunningham, E. W F W Alton, J. A. Innes

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Lung clearance index (LCI) is a sensitive marker of early lung disease in children but has not been assessed in adults. Measurement is hindered by the complexity of the equipment required. The aims of this study were to assess performance of a novel gas analyser (Innocor) and to use it as a clinical tool for the measurement of LCI in cystic fibrosis (CF). Methods: LCI was measured in 48 healthy adults, 12 healthy school-age children and 33 adults with CF by performing an inert gas washout from 0.2% sulfur hexafluoride (SF 6). SF6 signal:noise ratio and 10-90% rise time of Innocor were compared with a mass spectrometer used in similar studies in children. Results: Compared with the mass spectrometer, Innocor had a superior signal:noise ratio but a slower rise time (150 ms vs 60 ms) which may limit its use in very young children. Mean (SD) LCI in healthy adults was significantly different from that in patients with CF: 6.7 (0.4) vs 13.1 (3.8), p
    Original languageEnglish
    Pages (from-to)135-140
    Number of pages5
    JournalThorax
    Volume63
    Issue number2
    DOIs
    Publication statusPublished - Feb 2008

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