Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.

Anna Wrona; Fiona H Blackhall; Rolf A Stahel; Rafael Rosell; Fiona Blackhall; Urania Dafni; Keith M Kerr; Miquel Taron; Miguel Ángel Molina; Lukas Bubendorf; Walter Weder; Erik Thunnissen; Solange Peters; Anita Hiltbrunner; Rosita Kammler; Marc Marbot; Rudolf Maibach; Barbara Ruepp; Marie Kassapian; Varvara Polydoropoulou; Stavroula Poulopoulou; Peter Meldgaard; Henrik Hager; Anette Højsgaard; Alex Soltermann; Verena Tischler; Martina Storz; Bart Vrugt; Martina Friess; Alessandra Curioni; Kenneth O'Byrne; Stephen Finn; Eilish McGovern; Vincent Young; Steven Gray; Cathy Enright; Kathy Gately; Jan Walker; Martin Barr; Johan Vansteenkiste; Eric Verbeken; Kristiaan Nackaerts; Christophe Dooms; Christel Oyen; Liesbet Peeters; Stefanie Lepers; Liesbet Vliegen; T Roskams; Sara Van Der Borght; Peter Vandenberghe; Rafal Dziadziuszko; Wojciech Biernat; Aleksandra Sejda; Witold Rzyman; Jacek Jassem; Alicja Maciejewska-Izdebska; Enriqueta Felip; Javier Hernandez-Losa; Irene Sansano; Mercedes Canela; Núria Murtra Garrell; Antonio Marchetti; Sara Malatesta; Felice Mucilli; Luciana Irtelli; Fiamma Buttitta; Spasenija Savic; Didier Lardinois; Alfred Zippelius; Marianne Nicolson; Hardy Remmen; David A J Stevenson; Nicola Price; Shun Lu; Zhang Jie; Qiang Tan; Zhiwei Cheng; Egbert Smit; Coralien van Setten; Anne-Marie Dingemans; Ernst-Jan M Speel; Jos Maessen; Matyas Bendek; Alex A Adjei; Richard Cheney; Mary Beth Pine; Mary Reid; Carl Morrison; Elizabeth Taylor; Daisuke Nonaka; Jade Harris; Andrew Wallace; Rajesh Shah; Yvonne Summers; Anne Marie Quinn; Richard Booton; Paul Baas; Jeroen de Jong; Houke Klomp; Marianne Mahn; Marieke Groot Obbink; Efraim H Rosenberg; Petra Nederlof; Carlos Camps; Eloisa Jantus-Lewintre

doi:10.1097/JTO.0000000000000320

Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.

Anna Wrona, Fiona H Blackhall, Rolf A Stahel (Collaborator), Rafael Rosell (Collaborator), Fiona Blackhall (Collaborator), Urania Dafni (Collaborator), Keith M Kerr (Collaborator), Miquel Taron (Collaborator), Miguel Ángel Molina (Collaborator), Lukas Bubendorf (Collaborator), Walter Weder (Collaborator), Erik Thunnissen (Collaborator), Solange Peters (Collaborator), Anita Hiltbrunner (Collaborator), Rosita Kammler (Collaborator), Marc Marbot (Collaborator), Rudolf Maibach (Collaborator), Barbara Ruepp (Collaborator), Marie Kassapian (Collaborator), Varvara Polydoropoulou (Collaborator)Stavroula Poulopoulou (Collaborator), Peter Meldgaard (Collaborator), Henrik Hager (Collaborator), Anette Højsgaard (Collaborator), Alex Soltermann (Collaborator), Verena Tischler (Collaborator), Martina Storz (Collaborator), Bart Vrugt (Collaborator), Martina Friess (Collaborator), Alessandra Curioni (Collaborator), Kenneth O'Byrne (Collaborator), Stephen Finn (Collaborator), Eilish McGovern (Collaborator), Vincent Young (Collaborator), Steven Gray (Collaborator), Cathy Enright (Collaborator), Kathy Gately (Collaborator), Jan Walker (Collaborator), Martin Barr (Collaborator), Johan Vansteenkiste (Collaborator), Eric Verbeken (Collaborator), Kristiaan Nackaerts (Collaborator), Christophe Dooms (Collaborator), Christel Oyen (Collaborator), Liesbet Peeters (Collaborator), Stefanie Lepers (Collaborator), Liesbet Vliegen (Collaborator), T Roskams (Collaborator), Sara Van Der Borght (Collaborator), Peter Vandenberghe (Collaborator), Rafal Dziadziuszko (Collaborator), Wojciech Biernat (Collaborator), Aleksandra Sejda (Collaborator), Witold Rzyman (Collaborator), Jacek Jassem (Collaborator), Alicja Maciejewska-Izdebska (Collaborator), Enriqueta Felip (Collaborator), Javier Hernandez-Losa (Collaborator), Irene Sansano (Collaborator), Mercedes Canela (Collaborator), Núria Murtra Garrell (Collaborator), Antonio Marchetti (Collaborator), Sara Malatesta (Collaborator), Felice Mucilli (Collaborator), Luciana Irtelli (Collaborator), Fiamma Buttitta (Collaborator), Spasenija Savic (Collaborator), Didier Lardinois (Collaborator), Alfred Zippelius (Collaborator), Marianne Nicolson (Collaborator), Hardy Remmen (Collaborator), David A J Stevenson (Collaborator), Nicola Price (Collaborator), Shun Lu (Collaborator), Zhang Jie (Collaborator), Qiang Tan (Collaborator), Zhiwei Cheng (Collaborator), Egbert Smit (Collaborator), Coralien van Setten (Collaborator), Anne-Marie Dingemans (Collaborator), Ernst-Jan M Speel (Collaborator), Jos Maessen (Collaborator), Matyas Bendek (Collaborator), Alex A Adjei (Collaborator), Richard Cheney (Collaborator), Mary Beth Pine (Collaborator), Mary Reid (Collaborator), Carl Morrison (Collaborator), Elizabeth Taylor (Collaborator), Daisuke Nonaka (Collaborator), Jade Harris (Collaborator), Andrew Wallace (Collaborator), Rajesh Shah (Collaborator), Yvonne Summers (Collaborator), Anne Marie Quinn (Collaborator), Richard Booton (Collaborator), Paul Baas (Collaborator), Jeroen de Jong (Collaborator), Houke Klomp (Collaborator), Marianne Mahn (Collaborator), Marieke Groot Obbink (Collaborator), Efraim H Rosenberg (Collaborator), Petra Nederlof (Collaborator), Carlos Camps (Collaborator), Eloisa Jantus-Lewintre (Collaborator)

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: The Lungscape project was designed to address the impact of clinical, pathological, and molecular characteristics on outcome in resected non-small- cell lung cancer (NSCLC). MATERIALS AND METHODS: A decentralized biobank with fully annotated tissue samples was established. Selection criteria for participating centers included sufficient number of cases, tissue microarray building capability, and documented ethical approval. Patient selection was based on availability of comprehensive clinical data, radical resection between 2003 and 2009 with adequate follow-up, and adequate quantity and quality of formalin-fixed tissue. RESULTS: Fifteen centers contributed 2449 cases. The 5-year overall survival (OS) was 69.6% and 63.6% for stages IA and IB, 51.6% and 47.7% for stages IIA and IIB, and 29.0% and 13.0% for stages IIIA and IIIB, respectively (p <0.001). Median and 5-year relapse-free survival (RFS) were 52.8 months and 47.3%, respectively. Distant relapse was recorded for 44.4%, local for 26.0%, and both for 16.9% of patients. Based on multivariate analysis for the OS, RFS, and time to relapse, the factors significantly associated with all of them are performance status and pathological stage. CONCLUSION: The aim of this report is to present the results from Lungscape, the first large series reporting on NSCLC surgical outcome measured not only by OS but also by RFS and time to relapse and including multivariate analysis by significant clinical and pathological prognostic parameters. As tissue from all patients is preserved locally and is available for detailed molecular investigations, Lungscape provides an excellent basis to evaluate the influence of molecular parameters on the disease outcome after radical resection, besides providing an overview of the molecular landscape of stage I to III NSCLC.

Original language	English
Journal	Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Volume	9
Issue number	11
DOIs	https://doi.org/10.1097/JTO.0000000000000320
Publication status	Published - Nov 2014

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10.1097/JTO.0000000000000320

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Wrona, A., Blackhall, F. H., Stahel, R. A., Rosell, R., Blackhall, F., Dafni, U., Kerr, K. M., Taron, M., Molina, M. Á., Bubendorf, L., Weder, W., Thunnissen, E., Peters, S., Hiltbrunner, A., Kammler, R., Marbot, M., Maibach, R., Ruepp, B., Kassapian, M., ... Jantus-Lewintre, E. (2014). Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 9(11). https://doi.org/10.1097/JTO.0000000000000320

@article{6c857d4f7c444bea87324d50bfc352a9,

title = "Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.",

abstract = "INTRODUCTION: The Lungscape project was designed to address the impact of clinical, pathological, and molecular characteristics on outcome in resected non-small- cell lung cancer (NSCLC). MATERIALS AND METHODS: A decentralized biobank with fully annotated tissue samples was established. Selection criteria for participating centers included sufficient number of cases, tissue microarray building capability, and documented ethical approval. Patient selection was based on availability of comprehensive clinical data, radical resection between 2003 and 2009 with adequate follow-up, and adequate quantity and quality of formalin-fixed tissue. RESULTS: Fifteen centers contributed 2449 cases. The 5-year overall survival (OS) was 69.6\% and 63.6\% for stages IA and IB, 51.6\% and 47.7\% for stages IIA and IIB, and 29.0\% and 13.0\% for stages IIIA and IIIB, respectively (p <0.001). Median and 5-year relapse-free survival (RFS) were 52.8 months and 47.3\%, respectively. Distant relapse was recorded for 44.4\%, local for 26.0\%, and both for 16.9\% of patients. Based on multivariate analysis for the OS, RFS, and time to relapse, the factors significantly associated with all of them are performance status and pathological stage. CONCLUSION: The aim of this report is to present the results from Lungscape, the first large series reporting on NSCLC surgical outcome measured not only by OS but also by RFS and time to relapse and including multivariate analysis by significant clinical and pathological prognostic parameters. As tissue from all patients is preserved locally and is available for detailed molecular investigations, Lungscape provides an excellent basis to evaluate the influence of molecular parameters on the disease outcome after radical resection, besides providing an overview of the molecular landscape of stage I to III NSCLC.",

author = "Anna Wrona and Blackhall, \{Fiona H\} and Stahel, \{Rolf A\} and Rafael Rosell and Fiona Blackhall and Urania Dafni and Kerr, \{Keith M\} and Miquel Taron and Molina, \{Miguel {\'A}ngel\} and Lukas Bubendorf and Walter Weder and Erik Thunnissen and Solange Peters and Anita Hiltbrunner and Rosita Kammler and Marc Marbot and Rudolf Maibach and Barbara Ruepp and Marie Kassapian and Varvara Polydoropoulou and Stavroula Poulopoulou and Peter Meldgaard and Henrik Hager and Anette H{\o}jsgaard and Alex Soltermann and Verena Tischler and Martina Storz and Bart Vrugt and Martina Friess and Alessandra Curioni and Kenneth O'Byrne and Stephen Finn and Eilish McGovern and Vincent Young and Steven Gray and Cathy Enright and Kathy Gately and Jan Walker and Martin Barr and Johan Vansteenkiste and Eric Verbeken and Kristiaan Nackaerts and Christophe Dooms and Christel Oyen and Liesbet Peeters and Stefanie Lepers and Liesbet Vliegen and T Roskams and \{Van Der Borght\}, Sara and Peter Vandenberghe and Rafal Dziadziuszko and Wojciech Biernat and Aleksandra Sejda and Witold Rzyman and Jacek Jassem and Alicja Maciejewska-Izdebska and Enriqueta Felip and Javier Hernandez-Losa and Irene Sansano and Mercedes Canela and Garrell, \{N{\'u}ria Murtra\} and Antonio Marchetti and Sara Malatesta and Felice Mucilli and Luciana Irtelli and Fiamma Buttitta and Spasenija Savic and Didier Lardinois and Alfred Zippelius and Marianne Nicolson and Hardy Remmen and Stevenson, \{David A J\} and Nicola Price and Shun Lu and Zhang Jie and Qiang Tan and Zhiwei Cheng and Egbert Smit and \{van Setten\}, Coralien and Anne-Marie Dingemans and Speel, \{Ernst-Jan M\} and Jos Maessen and Matyas Bendek and Adjei, \{Alex A\} and Richard Cheney and Pine, \{Mary Beth\} and Mary Reid and Carl Morrison and Elizabeth Taylor and Daisuke Nonaka and Jade Harris and Andrew Wallace and Rajesh Shah and Yvonne Summers and Quinn, \{Anne Marie\} and Richard Booton and Paul Baas and \{de Jong\}, Jeroen and Houke Klomp and Marianne Mahn and Obbink, \{Marieke Groot\} and Rosenberg, \{Efraim H\} and Petra Nederlof and Carlos Camps and Eloisa Jantus-Lewintre",

year = "2014",

month = nov,

doi = "10.1097/JTO.0000000000000320",

language = "English",

volume = "9",

journal = "Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer",

issn = "1556-1380",

publisher = "Elsevier BV",

number = "11",

}

Wrona, A, Blackhall, FH, Stahel, RA, Rosell, R, Blackhall, F, Dafni, U, Kerr, KM, Taron, M, Molina, MÁ, Bubendorf, L, Weder, W, Thunnissen, E, Peters, S, Hiltbrunner, A, Kammler, R, Marbot, M, Maibach, R, Ruepp, B, Kassapian, M, Polydoropoulou, V, Poulopoulou, S, Meldgaard, P, Hager, H, Højsgaard, A, Soltermann, A, Tischler, V, Storz, M, Vrugt, B, Friess, M, Curioni, A, O'Byrne, K, Finn, S, McGovern, E, Young, V, Gray, S, Enright, C, Gately, K, Walker, J, Barr, M, Vansteenkiste, J, Verbeken, E, Nackaerts, K, Dooms, C, Oyen, C, Peeters, L, Lepers, S, Vliegen, L, Roskams, T, Van Der Borght, S, Vandenberghe, P, Dziadziuszko, R, Biernat, W, Sejda, A, Rzyman, W, Jassem, J, Maciejewska-Izdebska, A, Felip, E, Hernandez-Losa, J, Sansano, I, Canela, M, Garrell, NM, Marchetti, A, Malatesta, S, Mucilli, F, Irtelli, L, Buttitta, F, Savic, S, Lardinois, D, Zippelius, A, Nicolson, M, Remmen, H, Stevenson, DAJ, Price, N, Lu, S, Jie, Z, Tan, Q, Cheng, Z, Smit, E, van Setten, C, Dingemans, A-M, Speel, E-JM, Maessen, J, Bendek, M, Adjei, AA, Cheney, R, Pine, MB, Reid, M, Morrison, C, Taylor, E, Nonaka, D, Harris, J, Wallace, A, Shah, R, Summers, Y, Quinn, AM, Booton, R, Baas, P, de Jong, J, Klomp, H, Mahn, M, Obbink, MG, Rosenberg, EH, Nederlof, P, Camps, C & Jantus-Lewintre, E 2014, 'Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.', Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, vol. 9, no. 11. https://doi.org/10.1097/JTO.0000000000000320

Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters. / Wrona, Anna; Blackhall, Fiona H; Stahel, Rolf A (Collaborator) et al.
In: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 9, No. 11, 11.2014.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.

AU - Wrona, Anna

AU - Blackhall, Fiona H

A2 - Stahel, Rolf A

A2 - Rosell, Rafael

A2 - Blackhall, Fiona

A2 - Dafni, Urania

A2 - Kerr, Keith M

A2 - Taron, Miquel

A2 - Molina, Miguel Ángel

A2 - Bubendorf, Lukas

A2 - Weder, Walter

A2 - Thunnissen, Erik

A2 - Peters, Solange

A2 - Hiltbrunner, Anita

A2 - Kammler, Rosita

A2 - Marbot, Marc

A2 - Maibach, Rudolf

A2 - Ruepp, Barbara

A2 - Kassapian, Marie

A2 - Polydoropoulou, Varvara

A2 - Poulopoulou, Stavroula

A2 - Meldgaard, Peter

A2 - Hager, Henrik

A2 - Højsgaard, Anette

A2 - Soltermann, Alex

A2 - Tischler, Verena

A2 - Storz, Martina

A2 - Vrugt, Bart

A2 - Friess, Martina

A2 - Curioni, Alessandra

A2 - O'Byrne, Kenneth

A2 - Finn, Stephen

A2 - McGovern, Eilish

A2 - Young, Vincent

A2 - Gray, Steven

A2 - Enright, Cathy

A2 - Gately, Kathy

A2 - Walker, Jan

A2 - Barr, Martin

A2 - Vansteenkiste, Johan

A2 - Verbeken, Eric

A2 - Nackaerts, Kristiaan

A2 - Dooms, Christophe

A2 - Oyen, Christel

A2 - Peeters, Liesbet

A2 - Lepers, Stefanie

A2 - Vliegen, Liesbet

A2 - Roskams, T

A2 - Van Der Borght, Sara

A2 - Vandenberghe, Peter

A2 - Dziadziuszko, Rafal

A2 - Biernat, Wojciech

A2 - Sejda, Aleksandra

A2 - Rzyman, Witold

A2 - Jassem, Jacek

A2 - Maciejewska-Izdebska, Alicja

A2 - Felip, Enriqueta

A2 - Hernandez-Losa, Javier

A2 - Sansano, Irene

A2 - Canela, Mercedes

A2 - Garrell, Núria Murtra

A2 - Marchetti, Antonio

A2 - Malatesta, Sara

A2 - Mucilli, Felice

A2 - Irtelli, Luciana

A2 - Buttitta, Fiamma

A2 - Savic, Spasenija

A2 - Lardinois, Didier

A2 - Zippelius, Alfred

A2 - Nicolson, Marianne

A2 - Remmen, Hardy

A2 - Stevenson, David A J

A2 - Price, Nicola

A2 - Lu, Shun

A2 - Jie, Zhang

A2 - Tan, Qiang

A2 - Cheng, Zhiwei

A2 - Smit, Egbert

A2 - van Setten, Coralien

A2 - Dingemans, Anne-Marie

A2 - Speel, Ernst-Jan M

A2 - Maessen, Jos

A2 - Bendek, Matyas

A2 - Adjei, Alex A

A2 - Cheney, Richard

A2 - Pine, Mary Beth

A2 - Reid, Mary

A2 - Morrison, Carl

A2 - Taylor, Elizabeth

A2 - Nonaka, Daisuke

A2 - Harris, Jade

A2 - Wallace, Andrew

A2 - Shah, Rajesh

A2 - Summers, Yvonne

A2 - Quinn, Anne Marie

A2 - Booton, Richard

A2 - Baas, Paul

A2 - de Jong, Jeroen

A2 - Klomp, Houke

A2 - Mahn, Marianne

A2 - Obbink, Marieke Groot

A2 - Rosenberg, Efraim H

A2 - Nederlof, Petra

A2 - Camps, Carlos

A2 - Jantus-Lewintre, Eloisa

PY - 2014/11

Y1 - 2014/11

N2 - INTRODUCTION: The Lungscape project was designed to address the impact of clinical, pathological, and molecular characteristics on outcome in resected non-small- cell lung cancer (NSCLC). MATERIALS AND METHODS: A decentralized biobank with fully annotated tissue samples was established. Selection criteria for participating centers included sufficient number of cases, tissue microarray building capability, and documented ethical approval. Patient selection was based on availability of comprehensive clinical data, radical resection between 2003 and 2009 with adequate follow-up, and adequate quantity and quality of formalin-fixed tissue. RESULTS: Fifteen centers contributed 2449 cases. The 5-year overall survival (OS) was 69.6% and 63.6% for stages IA and IB, 51.6% and 47.7% for stages IIA and IIB, and 29.0% and 13.0% for stages IIIA and IIIB, respectively (p <0.001). Median and 5-year relapse-free survival (RFS) were 52.8 months and 47.3%, respectively. Distant relapse was recorded for 44.4%, local for 26.0%, and both for 16.9% of patients. Based on multivariate analysis for the OS, RFS, and time to relapse, the factors significantly associated with all of them are performance status and pathological stage. CONCLUSION: The aim of this report is to present the results from Lungscape, the first large series reporting on NSCLC surgical outcome measured not only by OS but also by RFS and time to relapse and including multivariate analysis by significant clinical and pathological prognostic parameters. As tissue from all patients is preserved locally and is available for detailed molecular investigations, Lungscape provides an excellent basis to evaluate the influence of molecular parameters on the disease outcome after radical resection, besides providing an overview of the molecular landscape of stage I to III NSCLC.

AB - INTRODUCTION: The Lungscape project was designed to address the impact of clinical, pathological, and molecular characteristics on outcome in resected non-small- cell lung cancer (NSCLC). MATERIALS AND METHODS: A decentralized biobank with fully annotated tissue samples was established. Selection criteria for participating centers included sufficient number of cases, tissue microarray building capability, and documented ethical approval. Patient selection was based on availability of comprehensive clinical data, radical resection between 2003 and 2009 with adequate follow-up, and adequate quantity and quality of formalin-fixed tissue. RESULTS: Fifteen centers contributed 2449 cases. The 5-year overall survival (OS) was 69.6% and 63.6% for stages IA and IB, 51.6% and 47.7% for stages IIA and IIB, and 29.0% and 13.0% for stages IIIA and IIIB, respectively (p <0.001). Median and 5-year relapse-free survival (RFS) were 52.8 months and 47.3%, respectively. Distant relapse was recorded for 44.4%, local for 26.0%, and both for 16.9% of patients. Based on multivariate analysis for the OS, RFS, and time to relapse, the factors significantly associated with all of them are performance status and pathological stage. CONCLUSION: The aim of this report is to present the results from Lungscape, the first large series reporting on NSCLC surgical outcome measured not only by OS but also by RFS and time to relapse and including multivariate analysis by significant clinical and pathological prognostic parameters. As tissue from all patients is preserved locally and is available for detailed molecular investigations, Lungscape provides an excellent basis to evaluate the influence of molecular parameters on the disease outcome after radical resection, besides providing an overview of the molecular landscape of stage I to III NSCLC.

UR - https://www.scopus.com/pages/publications/84925778718

U2 - 10.1097/JTO.0000000000000320

DO - 10.1097/JTO.0000000000000320

M3 - Article

C2 - 25436801

SN - 1556-1380

VL - 9

JO - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

IS - 11

ER -

Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.

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