Luteal phase defect: The possibility of an immunohistochemical diagnosis

M. W. Seif, J. D. Aplin, C. H. Buckley

    Research output: Contribution to journalArticlepeer-review


    Monoclonal antibody D9B1 has been shown to bind to a carbohydrate epitope associated with high molecular weight secretory sialoglycoprotein(s) of human endometrium. The authors demonstrate that, in a group of 28 patients diagnosed on the basis of histopathologic assessment as exhibiting luteal phase defect, 68% reveal significantly diminished expression of the epitope. Furthermore, histologic assessment of the secretory activity in single glands does not correlate simply with the level of expression of the epitope. Of specimens from patients complaining of infertility, 92% showed defective production of the D9B1 epitope. Thus, D9B1 immunohistochemistry provides a new molecular criterion for defective endometrial function.
    Original languageEnglish
    Pages (from-to)273-279
    Number of pages6
    JournalFertility and Sterility
    Issue number2
    Publication statusPublished - 1989


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