Macroglossia and amyloidoma of the buttock: Evidence of systemic involvement in dialysis amyloid

D. Sethi; A. J. Hutchison; N. R B Cary; E. A. Brown; J. R. Curtis; D. F. Woodrow; P. E. Gower

Macroglossia and amyloidoma of the buttock: Evidence of systemic involvement in dialysis amyloid

D. Sethi, A. J. Hutchison, N. R B Cary, E. A. Brown, J. R. Curtis, D. F. Woodrow, P. E. Gower

Research output: Contribution to journal › Article › peer-review

Abstract

A 48-year-old male on cuprophane haemodialysis for 18 years, with a history of dialysis arthropathy and recurrent carpal tunnel syndrome developed macroglossia and bilateral buttock tumoral masses. The tongue and buttock masses were biopsied. Histology of both biopsies showed amyloid deposits of the β2-microglobulin (B2M) variety. Amyloidomas in the gluteal region and macroglossia have not been previously described in amyloid derived from B2M. These findings suggest that systemic B2M amyloidosis can have a similar tissue distribution to AL amyloidosis. This case also stresses the importance of inspection of the tongue, and palpation of the gluteal region for masses, in the assessment of patients with dialysis arthropathy.

Original language	English
Pages (from-to)	312-315
Number of pages	3
Journal	Nephron
Volume	55
Issue number	3
Publication status	Published - 1990

Keywords

β2-microglobulin
amyloidoma
haemodialysis
macroglossia

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title = "Macroglossia and amyloidoma of the buttock: Evidence of systemic involvement in dialysis amyloid",

abstract = "A 48-year-old male on cuprophane haemodialysis for 18 years, with a history of dialysis arthropathy and recurrent carpal tunnel syndrome developed macroglossia and bilateral buttock tumoral masses. The tongue and buttock masses were biopsied. Histology of both biopsies showed amyloid deposits of the β2-microglobulin (B2M) variety. Amyloidomas in the gluteal region and macroglossia have not been previously described in amyloid derived from B2M. These findings suggest that systemic B2M amyloidosis can have a similar tissue distribution to AL amyloidosis. This case also stresses the importance of inspection of the tongue, and palpation of the gluteal region for masses, in the assessment of patients with dialysis arthropathy.",

keywords = "β2-microglobulin, amyloidoma, haemodialysis, macroglossia",

author = "D. Sethi and Hutchison, {A. J.} and Cary, {N. R B} and Brown, {E. A.} and Curtis, {J. R.} and Woodrow, {D. F.} and Gower, {P. E.}",

year = "1990",

language = "English",

volume = "55",

pages = "312--315",

journal = "Nephron",

issn = "0028-2766",

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TY - JOUR

T1 - Macroglossia and amyloidoma of the buttock: Evidence of systemic involvement in dialysis amyloid

AU - Sethi, D.

AU - Hutchison, A. J.

AU - Cary, N. R B

AU - Brown, E. A.

AU - Curtis, J. R.

AU - Woodrow, D. F.

AU - Gower, P. E.

PY - 1990

Y1 - 1990

N2 - A 48-year-old male on cuprophane haemodialysis for 18 years, with a history of dialysis arthropathy and recurrent carpal tunnel syndrome developed macroglossia and bilateral buttock tumoral masses. The tongue and buttock masses were biopsied. Histology of both biopsies showed amyloid deposits of the β2-microglobulin (B2M) variety. Amyloidomas in the gluteal region and macroglossia have not been previously described in amyloid derived from B2M. These findings suggest that systemic B2M amyloidosis can have a similar tissue distribution to AL amyloidosis. This case also stresses the importance of inspection of the tongue, and palpation of the gluteal region for masses, in the assessment of patients with dialysis arthropathy.

AB - A 48-year-old male on cuprophane haemodialysis for 18 years, with a history of dialysis arthropathy and recurrent carpal tunnel syndrome developed macroglossia and bilateral buttock tumoral masses. The tongue and buttock masses were biopsied. Histology of both biopsies showed amyloid deposits of the β2-microglobulin (B2M) variety. Amyloidomas in the gluteal region and macroglossia have not been previously described in amyloid derived from B2M. These findings suggest that systemic B2M amyloidosis can have a similar tissue distribution to AL amyloidosis. This case also stresses the importance of inspection of the tongue, and palpation of the gluteal region for masses, in the assessment of patients with dialysis arthropathy.

KW - β2-microglobulin

KW - amyloidoma

KW - haemodialysis

KW - macroglossia

M3 - Article

C2 - 2196475

SN - 0028-2766

VL - 55

SP - 312

EP - 315

JO - Nephron

JF - Nephron

IS - 3

ER -

Macroglossia and amyloidoma of the buttock: Evidence of systemic involvement in dialysis amyloid

Abstract

Keywords

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