Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis

Rachelle P. Donn; Darren Plant; Francine Jury; Helen L. Richards; Jane Worthington; David W. Ray; Christopher E M Griffiths

doi:10.1111/j.0022-202X.2004.23314.x

Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis

Rachelle P. Donn, Darren Plant, Francine Jury, Helen L. Richards, Jane Worthington, David W. Ray, Christopher E M Griffiths

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine, is over-expressed in plaques of psoriasis and increased levels are found in the sera of patients with psoriasis. Promoter polymorphisms of the MIF gene are associated with increased production of MIF and have been found to confer increased risk of susceptibility to chronic inflammatory diseases. We investigated whether there is an association between promoter polymorphisms of the MIF gene and chronic plaque psoriasis. Two hundred and twenty-eight UK caucasian patients with chronic plaque psoriasis, and a control panel of 401 UK caucasian normal volunteers were studied. MIF promoter polymorphisms were genotyped by allelic discrimination, or by a fluorescently labeled primer method, and capillary gel electrophoresis. Carriage of either the MIF-173*C polymorphism or the MIF CATT7 polymorphism was positively correlated with psoriasis (odds ratios (OR) 1.52 95% confidence intervals (CI) 1.05-2.19 (p = 0.024) and OR 1.67 95% CI 1.1-2.5 (p = 0.013), respectively. The OR for presence of the CATT7-MIF-173*C haplotype versus all other haplotypes combined was 1.69 95% CI 1.2-2.5 (p = 0.008). The results provide evidence for polymorphisms in the MIF gene, and in particular the CATT7-MIF-173*C haplotype, being of importance in susceptibility to psoriasis.

Original language	English
Pages (from-to)	484-487
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	123
Issue number	3
DOIs	https://doi.org/10.1111/j.0022-202X.2004.23314.x
Publication status	Published - Sept 2004

Keywords

Inflammation
MIF
Plaque psoriasis
SNP

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title = "Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis",

abstract = "Macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine, is over-expressed in plaques of psoriasis and increased levels are found in the sera of patients with psoriasis. Promoter polymorphisms of the MIF gene are associated with increased production of MIF and have been found to confer increased risk of susceptibility to chronic inflammatory diseases. We investigated whether there is an association between promoter polymorphisms of the MIF gene and chronic plaque psoriasis. Two hundred and twenty-eight UK caucasian patients with chronic plaque psoriasis, and a control panel of 401 UK caucasian normal volunteers were studied. MIF promoter polymorphisms were genotyped by allelic discrimination, or by a fluorescently labeled primer method, and capillary gel electrophoresis. Carriage of either the MIF-173*C polymorphism or the MIF CATT7 polymorphism was positively correlated with psoriasis (odds ratios (OR) 1.52 95% confidence intervals (CI) 1.05-2.19 (p = 0.024) and OR 1.67 95% CI 1.1-2.5 (p = 0.013), respectively. The OR for presence of the CATT7-MIF-173*C haplotype versus all other haplotypes combined was 1.69 95% CI 1.2-2.5 (p = 0.008). The results provide evidence for polymorphisms in the MIF gene, and in particular the CATT7-MIF-173*C haplotype, being of importance in susceptibility to psoriasis.",

keywords = "Inflammation, MIF, Plaque psoriasis, SNP",

author = "Donn, {Rachelle P.} and Darren Plant and Francine Jury and Richards, {Helen L.} and Jane Worthington and Ray, {David W.} and Griffiths, {Christopher E M}",

year = "2004",

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doi = "10.1111/j.0022-202X.2004.23314.x",

language = "English",

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T1 - Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis

AU - Donn, Rachelle P.

AU - Plant, Darren

AU - Jury, Francine

AU - Richards, Helen L.

AU - Worthington, Jane

AU - Ray, David W.

AU - Griffiths, Christopher E M

PY - 2004/9

Y1 - 2004/9

N2 - Macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine, is over-expressed in plaques of psoriasis and increased levels are found in the sera of patients with psoriasis. Promoter polymorphisms of the MIF gene are associated with increased production of MIF and have been found to confer increased risk of susceptibility to chronic inflammatory diseases. We investigated whether there is an association between promoter polymorphisms of the MIF gene and chronic plaque psoriasis. Two hundred and twenty-eight UK caucasian patients with chronic plaque psoriasis, and a control panel of 401 UK caucasian normal volunteers were studied. MIF promoter polymorphisms were genotyped by allelic discrimination, or by a fluorescently labeled primer method, and capillary gel electrophoresis. Carriage of either the MIF-173*C polymorphism or the MIF CATT7 polymorphism was positively correlated with psoriasis (odds ratios (OR) 1.52 95% confidence intervals (CI) 1.05-2.19 (p = 0.024) and OR 1.67 95% CI 1.1-2.5 (p = 0.013), respectively. The OR for presence of the CATT7-MIF-173*C haplotype versus all other haplotypes combined was 1.69 95% CI 1.2-2.5 (p = 0.008). The results provide evidence for polymorphisms in the MIF gene, and in particular the CATT7-MIF-173*C haplotype, being of importance in susceptibility to psoriasis.

AB - Macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine, is over-expressed in plaques of psoriasis and increased levels are found in the sera of patients with psoriasis. Promoter polymorphisms of the MIF gene are associated with increased production of MIF and have been found to confer increased risk of susceptibility to chronic inflammatory diseases. We investigated whether there is an association between promoter polymorphisms of the MIF gene and chronic plaque psoriasis. Two hundred and twenty-eight UK caucasian patients with chronic plaque psoriasis, and a control panel of 401 UK caucasian normal volunteers were studied. MIF promoter polymorphisms were genotyped by allelic discrimination, or by a fluorescently labeled primer method, and capillary gel electrophoresis. Carriage of either the MIF-173*C polymorphism or the MIF CATT7 polymorphism was positively correlated with psoriasis (odds ratios (OR) 1.52 95% confidence intervals (CI) 1.05-2.19 (p = 0.024) and OR 1.67 95% CI 1.1-2.5 (p = 0.013), respectively. The OR for presence of the CATT7-MIF-173*C haplotype versus all other haplotypes combined was 1.69 95% CI 1.2-2.5 (p = 0.008). The results provide evidence for polymorphisms in the MIF gene, and in particular the CATT7-MIF-173*C haplotype, being of importance in susceptibility to psoriasis.

KW - Inflammation

KW - MIF

KW - Plaque psoriasis

KW - SNP

U2 - 10.1111/j.0022-202X.2004.23314.x

DO - 10.1111/j.0022-202X.2004.23314.x

M3 - Article

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

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ER -

Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis

Abstract

Keywords

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