Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter

K. E. Mcaleese; M. Firbank; D. Hunter; L. Sun; R. Hall; J. W. Neal; D. M A Mann; M. Esiri; K. A. Jellinger; J. T. O'Brien; J. Attems

doi:10.1111/j.1365-2990.2012.01310.x

Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter

K. E. Mcaleese, M. Firbank, D. Hunter, L. Sun, R. Hall, J. W. Neal, D. M A Mann, M. Esiri, K. A. Jellinger, J. T. O'Brien, J. Attems

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: Subcortical vascular pathology of the white and deep grey matter (WM and DGM) is associated with cognitive impairment. Routine neuropathological assessment of subcortical vascular pathology is based on semiquantitative scoring of characteristic lesions in a limited number of histological slides from selected WM and DGM areas. Clinically, WM and DGM lesions are visualized as hyper-intensities on magnetic resonance imaging (MRI). The aim of this study was to evaluate the feasibility of MRI on fixed post mortem brain hemispheres to complement routine neuropathological assessment of subcortical vascular pathology. Methods: We assessed subcortical vascular pathology in 40 post mortem brain hemispheres from demented (n=26) and nondemented (n=14) individuals (mean age 83.2±14.8 years; 62.5% female) using (i) routine histological assessment; (ii) extensive histological assessment of the entire hemisphere at 7-mm intervals; and (iii) full T2-weighted MRI performed on fixed post mortem brain hemispheres. Results: In both WM and DGM routine histological scores for subcortical vascular pathology were significantly lower (P

Original language	English
Pages (from-to)	485-497
Number of pages	12
Journal	Neuropathology and Applied Neurobiology
Volume	39
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2990.2012.01310.x
Publication status	Published - Aug 2013

Keywords

Magnetic resonance imaging
Neuropathology
post mortem
Subcortical vascular pathology
White matter lesions

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10.1111/j.1365-2990.2012.01310.x

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Mcaleese, K. E., Firbank, M., Hunter, D., Sun, L., Hall, R., Neal, J. W., Mann, D. M. A., Esiri, M., Jellinger, K. A., O'Brien, J. T., & Attems, J. (2013). Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter. Neuropathology and Applied Neurobiology, 39(5), 485-497. https://doi.org/10.1111/j.1365-2990.2012.01310.x

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title = "Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter",

abstract = "Aims: Subcortical vascular pathology of the white and deep grey matter (WM and DGM) is associated with cognitive impairment. Routine neuropathological assessment of subcortical vascular pathology is based on semiquantitative scoring of characteristic lesions in a limited number of histological slides from selected WM and DGM areas. Clinically, WM and DGM lesions are visualized as hyper-intensities on magnetic resonance imaging (MRI). The aim of this study was to evaluate the feasibility of MRI on fixed post mortem brain hemispheres to complement routine neuropathological assessment of subcortical vascular pathology. Methods: We assessed subcortical vascular pathology in 40 post mortem brain hemispheres from demented (n=26) and nondemented (n=14) individuals (mean age 83.2±14.8 years; 62.5% female) using (i) routine histological assessment; (ii) extensive histological assessment of the entire hemisphere at 7-mm intervals; and (iii) full T2-weighted MRI performed on fixed post mortem brain hemispheres. Results: In both WM and DGM routine histological scores for subcortical vascular pathology were significantly lower (P",

keywords = "Magnetic resonance imaging, Neuropathology, post mortem, Subcortical vascular pathology, White matter lesions",

author = "Mcaleese, {K. E.} and M. Firbank and D. Hunter and L. Sun and R. Hall and Neal, {J. W.} and Mann, {D. M A} and M. Esiri and Jellinger, {K. A.} and O'Brien, {J. T.} and J. Attems",

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month = aug,

doi = "10.1111/j.1365-2990.2012.01310.x",

language = "English",

volume = "39",

pages = "485--497",

journal = "Neuropathology and Applied Neurobiology",

issn = "1365-2990",

publisher = "John Wiley & Sons Ltd",

number = "5",

}

Mcaleese, KE, Firbank, M, Hunter, D, Sun, L, Hall, R, Neal, JW, Mann, DMA, Esiri, M, Jellinger, KA, O'Brien, JT & Attems, J 2013, 'Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter', Neuropathology and Applied Neurobiology, vol. 39, no. 5, pp. 485-497. https://doi.org/10.1111/j.1365-2990.2012.01310.x

TY - JOUR

T1 - Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter

AU - Mcaleese, K. E.

AU - Firbank, M.

AU - Hunter, D.

AU - Sun, L.

AU - Hall, R.

AU - Neal, J. W.

AU - Mann, D. M A

AU - Esiri, M.

AU - Jellinger, K. A.

AU - O'Brien, J. T.

AU - Attems, J.

PY - 2013/8

Y1 - 2013/8

N2 - Aims: Subcortical vascular pathology of the white and deep grey matter (WM and DGM) is associated with cognitive impairment. Routine neuropathological assessment of subcortical vascular pathology is based on semiquantitative scoring of characteristic lesions in a limited number of histological slides from selected WM and DGM areas. Clinically, WM and DGM lesions are visualized as hyper-intensities on magnetic resonance imaging (MRI). The aim of this study was to evaluate the feasibility of MRI on fixed post mortem brain hemispheres to complement routine neuropathological assessment of subcortical vascular pathology. Methods: We assessed subcortical vascular pathology in 40 post mortem brain hemispheres from demented (n=26) and nondemented (n=14) individuals (mean age 83.2±14.8 years; 62.5% female) using (i) routine histological assessment; (ii) extensive histological assessment of the entire hemisphere at 7-mm intervals; and (iii) full T2-weighted MRI performed on fixed post mortem brain hemispheres. Results: In both WM and DGM routine histological scores for subcortical vascular pathology were significantly lower (P

AB - Aims: Subcortical vascular pathology of the white and deep grey matter (WM and DGM) is associated with cognitive impairment. Routine neuropathological assessment of subcortical vascular pathology is based on semiquantitative scoring of characteristic lesions in a limited number of histological slides from selected WM and DGM areas. Clinically, WM and DGM lesions are visualized as hyper-intensities on magnetic resonance imaging (MRI). The aim of this study was to evaluate the feasibility of MRI on fixed post mortem brain hemispheres to complement routine neuropathological assessment of subcortical vascular pathology. Methods: We assessed subcortical vascular pathology in 40 post mortem brain hemispheres from demented (n=26) and nondemented (n=14) individuals (mean age 83.2±14.8 years; 62.5% female) using (i) routine histological assessment; (ii) extensive histological assessment of the entire hemisphere at 7-mm intervals; and (iii) full T2-weighted MRI performed on fixed post mortem brain hemispheres. Results: In both WM and DGM routine histological scores for subcortical vascular pathology were significantly lower (P

KW - Magnetic resonance imaging

KW - Neuropathology

KW - post mortem

KW - Subcortical vascular pathology

KW - White matter lesions

U2 - 10.1111/j.1365-2990.2012.01310.x

DO - 10.1111/j.1365-2990.2012.01310.x

M3 - Article

C2 - 23075072

VL - 39

SP - 485

EP - 497

JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

SN - 1365-2990

IS - 5

ER -

Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter

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Keywords

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