Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models

Xiao Ping Zhu, An Tao Du, Geon Ho Jahng, Brian J. Soher, Andrew A. Maudsley, Michael W. Weiner, Norbert Schuff

    Research output: Contribution to journalArticlepeer-review


    A new method, based on a deformable shape-intensity model (DSM), was developed to improve the signal-to-noise ratio (SNR) of multidimensional magnetic resonance spectroscopic imaging (MRSI) data sets without affecting spectral lineshapes and linewidths. Improvements with DSM, compared to digital filters using conventional signal apodization, were demonstrated on both simulated and experimental in vivo 1H MRS images from 22 cognitively normal (CN) elderly subjects and 25 patients with Alzheimer's disease (AD). Simulated MRSI data showed that DSM achieved superior noise suppression compared to a matched apodization filter. Experimental MRSI data showed that SNR could be increased 2.1-fold with DSM without distorting spectral resolution, thus maintaining all spectral features of the raw, unfiltered data. In conclusion, DSM should be used to achieve high SNR in reconstructing MRSI data. © 2003 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)474-482
    Number of pages8
    JournalMagnetic Resonance in Medicine
    Issue number3
    Publication statusPublished - 1 Sept 2003


    • Deformable shape-intensity model
    • Magnetic resonance spectroscopic imaging
    • Noise reduction
    • Spectral analysis


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