Magnitude and attributed reasons for adult weight gain amongst women at increased risk of breast cancer

Mary Pegington; Elaine F Harkness; Anthony Howell; D Gareth Evans; Michelle Harvie

doi:10.1186/s12905-022-02037-w

Magnitude and attributed reasons for adult weight gain amongst women at increased risk of breast cancer

Mary Pegington, Elaine F Harkness, Anthony Howell, D Gareth Evans, Michelle Harvie

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Excess weight (BMI ≥25.0 kg/m<sup>2</sup>) and weight gain during adult life increase the risk of postmenopausal breast cancer in women who are already at increased risk of the disease. Reasons for weight gain in this population can inform strategies for weight gain prevention.

METHODS: Baseline data from six weight loss studies for women at increased risk of breast cancer (age 31-74 years) were collated. Self-reported patterns of adult weight gain and attributed reasons for weight gain before joining the weight loss study were reported for the whole population and secondary analyses reported the different reasons given by women with/without children, pre-/peri- or postmenopausal, and moderate/high risk of breast cancer.

RESULTS: Five hundred and one women with a mean age of 47.6 (SD 8.4) years and median BMI of 29.9 (IQR 27.0-34.7) kg/m<sup>2</sup> were included in the analyses. The median weight gain since young adulthood (18-20 years) was 20.5 (IQR 14.0-29.7) kg or 33.7 (23.4-50.2) % and median annual weight gain was 0.73 (IQR 0.51-1.08) kg. Four hundred and one women were included in analysis of weight gain reasons. The main five self-reported reasons for weight gain were children / childcare / pregnancy (stated by 55.9% of participants), followed by inactivity (41.9%), comfort or boredom eating (38.2%), portion size (32.4%), and stress (27.4%). Reasons appeared broadly similar between the different groups in the secondary analyses.

CONCLUSIONS: We have highlighted common reasons for weight gain in women at increased risk of breast cancer. This will inform future interventions to support women to avoid weight gain in adulthood which would reduce the burden of breast cancer.

TRIAL REGISTRATION: NIHR NRR N0226132725, ISRCTN52913838, ISRCTN77916487, ISRCTN91372184, ISRCTN10803394 and ISRCTN16431108.

Original language	English
Article number	447
Journal	BMC Women's Health
Volume	22
Issue number	1
Early online date	12 Nov 2022
DOIs	https://doi.org/10.1186/s12905-022-02037-w
Publication status	Published - 1 Dec 2022

Keywords

Adult
Pregnancy
Child
Female
Humans
Young Adult
Middle Aged
Aged
Breast Neoplasms/complications
Body Mass Index
Postmenopause
Obesity/epidemiology
Risk Factors
Weight Gain
Weight Loss

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12905-022-02037-w

Cite this

@article{2e6eedd1bb6342d49dd0369b41328f4f,

title = "Magnitude and attributed reasons for adult weight gain amongst women at increased risk of breast cancer",

abstract = "BACKGROUND: Excess weight (BMI ≥25.0 kg/m2) and weight gain during adult life increase the risk of postmenopausal breast cancer in women who are already at increased risk of the disease. Reasons for weight gain in this population can inform strategies for weight gain prevention.METHODS: Baseline data from six weight loss studies for women at increased risk of breast cancer (age 31-74 years) were collated. Self-reported patterns of adult weight gain and attributed reasons for weight gain before joining the weight loss study were reported for the whole population and secondary analyses reported the different reasons given by women with/without children, pre-/peri- or postmenopausal, and moderate/high risk of breast cancer.RESULTS: Five hundred and one women with a mean age of 47.6 (SD 8.4) years and median BMI of 29.9 (IQR 27.0-34.7) kg/m2 were included in the analyses. The median weight gain since young adulthood (18-20 years) was 20.5 (IQR 14.0-29.7) kg or 33.7 (23.4-50.2) % and median annual weight gain was 0.73 (IQR 0.51-1.08) kg. Four hundred and one women were included in analysis of weight gain reasons. The main five self-reported reasons for weight gain were children / childcare / pregnancy (stated by 55.9% of participants), followed by inactivity (41.9%), comfort or boredom eating (38.2%), portion size (32.4%), and stress (27.4%). Reasons appeared broadly similar between the different groups in the secondary analyses.CONCLUSIONS: We have highlighted common reasons for weight gain in women at increased risk of breast cancer. This will inform future interventions to support women to avoid weight gain in adulthood which would reduce the burden of breast cancer.TRIAL REGISTRATION: NIHR NRR N0226132725, ISRCTN52913838, ISRCTN77916487, ISRCTN91372184, ISRCTN10803394 and ISRCTN16431108.",

keywords = "Adult, Pregnancy, Child, Female, Humans, Young Adult, Middle Aged, Aged, Breast Neoplasms/complications, Body Mass Index, Postmenopause, Obesity/epidemiology, Risk Factors, Weight Gain, Weight Loss",

author = "Mary Pegington and Harkness, {Elaine F} and Anthony Howell and Evans, {D Gareth} and Michelle Harvie",

note = "Funding Information: Funding for the included studies is detailed in Table . None of the funding bodies played a role in the design of the study and collection, analysis, and interpretation of data or in writing this manuscript. MP and DGE are supported by the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre (BRC1215–20007). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

day = "1",

doi = "10.1186/s12905-022-02037-w",

language = "English",

volume = "22",

journal = "BMC Women's Health",

issn = "1472-6874",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Magnitude and attributed reasons for adult weight gain amongst women at increased risk of breast cancer

AU - Pegington, Mary

AU - Harkness, Elaine F

AU - Howell, Anthony

AU - Evans, D Gareth

AU - Harvie, Michelle

N1 - Funding Information: Funding for the included studies is detailed in Table . None of the funding bodies played a role in the design of the study and collection, analysis, and interpretation of data or in writing this manuscript. MP and DGE are supported by the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre (BRC1215–20007). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12/1

Y1 - 2022/12/1

N2 - BACKGROUND: Excess weight (BMI ≥25.0 kg/m2) and weight gain during adult life increase the risk of postmenopausal breast cancer in women who are already at increased risk of the disease. Reasons for weight gain in this population can inform strategies for weight gain prevention.METHODS: Baseline data from six weight loss studies for women at increased risk of breast cancer (age 31-74 years) were collated. Self-reported patterns of adult weight gain and attributed reasons for weight gain before joining the weight loss study were reported for the whole population and secondary analyses reported the different reasons given by women with/without children, pre-/peri- or postmenopausal, and moderate/high risk of breast cancer.RESULTS: Five hundred and one women with a mean age of 47.6 (SD 8.4) years and median BMI of 29.9 (IQR 27.0-34.7) kg/m2 were included in the analyses. The median weight gain since young adulthood (18-20 years) was 20.5 (IQR 14.0-29.7) kg or 33.7 (23.4-50.2) % and median annual weight gain was 0.73 (IQR 0.51-1.08) kg. Four hundred and one women were included in analysis of weight gain reasons. The main five self-reported reasons for weight gain were children / childcare / pregnancy (stated by 55.9% of participants), followed by inactivity (41.9%), comfort or boredom eating (38.2%), portion size (32.4%), and stress (27.4%). Reasons appeared broadly similar between the different groups in the secondary analyses.CONCLUSIONS: We have highlighted common reasons for weight gain in women at increased risk of breast cancer. This will inform future interventions to support women to avoid weight gain in adulthood which would reduce the burden of breast cancer.TRIAL REGISTRATION: NIHR NRR N0226132725, ISRCTN52913838, ISRCTN77916487, ISRCTN91372184, ISRCTN10803394 and ISRCTN16431108.

AB - BACKGROUND: Excess weight (BMI ≥25.0 kg/m2) and weight gain during adult life increase the risk of postmenopausal breast cancer in women who are already at increased risk of the disease. Reasons for weight gain in this population can inform strategies for weight gain prevention.METHODS: Baseline data from six weight loss studies for women at increased risk of breast cancer (age 31-74 years) were collated. Self-reported patterns of adult weight gain and attributed reasons for weight gain before joining the weight loss study were reported for the whole population and secondary analyses reported the different reasons given by women with/without children, pre-/peri- or postmenopausal, and moderate/high risk of breast cancer.RESULTS: Five hundred and one women with a mean age of 47.6 (SD 8.4) years and median BMI of 29.9 (IQR 27.0-34.7) kg/m2 were included in the analyses. The median weight gain since young adulthood (18-20 years) was 20.5 (IQR 14.0-29.7) kg or 33.7 (23.4-50.2) % and median annual weight gain was 0.73 (IQR 0.51-1.08) kg. Four hundred and one women were included in analysis of weight gain reasons. The main five self-reported reasons for weight gain were children / childcare / pregnancy (stated by 55.9% of participants), followed by inactivity (41.9%), comfort or boredom eating (38.2%), portion size (32.4%), and stress (27.4%). Reasons appeared broadly similar between the different groups in the secondary analyses.CONCLUSIONS: We have highlighted common reasons for weight gain in women at increased risk of breast cancer. This will inform future interventions to support women to avoid weight gain in adulthood which would reduce the burden of breast cancer.TRIAL REGISTRATION: NIHR NRR N0226132725, ISRCTN52913838, ISRCTN77916487, ISRCTN91372184, ISRCTN10803394 and ISRCTN16431108.

KW - Adult

KW - Pregnancy

KW - Child

KW - Female

KW - Humans

KW - Young Adult

KW - Middle Aged

KW - Aged

KW - Breast Neoplasms/complications

KW - Body Mass Index

KW - Postmenopause

KW - Obesity/epidemiology

KW - Risk Factors

KW - Weight Gain

KW - Weight Loss

U2 - 10.1186/s12905-022-02037-w

DO - 10.1186/s12905-022-02037-w

M3 - Article

C2 - 36371176

SN - 1472-6874

VL - 22

JO - BMC Women's Health

JF - BMC Women's Health

IS - 1

M1 - 447

ER -

Magnitude and attributed reasons for adult weight gain amongst women at increased risk of breast cancer

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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