MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

Jana Vondrakova; Michaela Frolikova; Lukas Ded; Jiri Cerny; Pavla Postlerova; Veronika Palenikova; Ondrej Simonik; Zuzana Nahacka; Krystof Basus; Eliska Valaskova; Radek Machan; Allan Pacey; Zuzana Holubcova; Pavel Koubek; Zuzana Ezrova; Soojin Park; Ruiwu Liu; Raghavendran Partha; Nathan Clark; Jiri Neuzil; Masahito Ikawa; Kent Erickson; Kit S Lam; Harry Moore; Katerina Komrskova

doi:10.1126/sciadv.abn0047

MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

Jana Vondrakova, Michaela Frolikova, Lukas Ded, Jiri Cerny, Pavla Postlerova, Veronika Palenikova, Ondrej Simonik, Zuzana Nahacka, Krystof Basus, Eliska Valaskova, Radek Machan, Allan Pacey, Zuzana Holubcova, Pavel Koubek, Zuzana Ezrova, Soojin Park, Ruiwu Liu, Raghavendran Partha, Nathan Clark, Jiri NeuzilMasahito Ikawa, Kent Erickson, Kit S Lam, Harry Moore, Katerina Komrskova

Division of Developmental Biology & Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.

Original language	English
Article number	eabn0047
Journal	Science Advances
Volume	8
Issue number	36
DOIs	https://doi.org/10.1126/sciadv.abn0047
Publication status	Published - 9 Sept 2022

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Vondrakova, J., Frolikova, M., Ded, L., Cerny, J., Postlerova, P., Palenikova, V., Simonik, O., Nahacka, Z., Basus, K., Valaskova, E., Machan, R., Pacey, A., Holubcova, Z., Koubek, P., Ezrova, Z., Park, S., Liu, R., Partha, R., Clark, N., ... Komrskova, K. (2022). MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization. Science Advances, 8(36), Article eabn0047. https://doi.org/10.1126/sciadv.abn0047

@article{de234daeedff4d65938e9cb20b09ec44,

title = "MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization",

abstract = "Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.",

author = "Jana Vondrakova and Michaela Frolikova and Lukas Ded and Jiri Cerny and Pavla Postlerova and Veronika Palenikova and Ondrej Simonik and Zuzana Nahacka and Krystof Basus and Eliska Valaskova and Radek Machan and Allan Pacey and Zuzana Holubcova and Pavel Koubek and Zuzana Ezrova and Soojin Park and Ruiwu Liu and Raghavendran Partha and Nathan Clark and Jiri Neuzil and Masahito Ikawa and Kent Erickson and Lam, {Kit S} and Harry Moore and Katerina Komrskova",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).",

year = "2022",

month = sep,

day = "9",

doi = "10.1126/sciadv.abn0047",

language = "English",

volume = "8",

journal = "Science Advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science (A A A S)",

number = "36",

}

Vondrakova, J, Frolikova, M, Ded, L, Cerny, J, Postlerova, P, Palenikova, V, Simonik, O, Nahacka, Z, Basus, K, Valaskova, E, Machan, R, Pacey, A, Holubcova, Z, Koubek, P, Ezrova, Z, Park, S, Liu, R, Partha, R, Clark, N, Neuzil, J, Ikawa, M, Erickson, K, Lam, KS, Moore, H & Komrskova, K 2022, 'MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization', Science Advances, vol. 8, no. 36, eabn0047. https://doi.org/10.1126/sciadv.abn0047

TY - JOUR

T1 - MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

AU - Vondrakova, Jana

AU - Frolikova, Michaela

AU - Ded, Lukas

AU - Cerny, Jiri

AU - Postlerova, Pavla

AU - Palenikova, Veronika

AU - Simonik, Ondrej

AU - Nahacka, Zuzana

AU - Basus, Krystof

AU - Valaskova, Eliska

AU - Machan, Radek

AU - Pacey, Allan

AU - Holubcova, Zuzana

AU - Koubek, Pavel

AU - Ezrova, Zuzana

AU - Park, Soojin

AU - Liu, Ruiwu

AU - Partha, Raghavendran

AU - Clark, Nathan

AU - Neuzil, Jiri

AU - Ikawa, Masahito

AU - Erickson, Kent

AU - Lam, Kit S

AU - Moore, Harry

AU - Komrskova, Katerina

N1 - Publisher Copyright: Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

PY - 2022/9/9

Y1 - 2022/9/9

N2 - Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.

AB - Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.

U2 - 10.1126/sciadv.abn0047

DO - 10.1126/sciadv.abn0047

M3 - Article

C2 - 36070373

SN - 2375-2548

VL - 8

JO - Science Advances

JF - Science Advances

IS - 36

M1 - eabn0047

ER -

MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

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