Making new out of old: Recycling and modification of an ancient protein translocation system during eukaryotic evolution

Kathrin Bolte; Nicole Gruenheit; Gregor Felsner; Maik S. Sommer; Uwe G. Maier; Franziska Hempel

doi:10.1002/bies.201100007

Making new out of old: Recycling and modification of an ancient protein translocation system during eukaryotic evolution

Kathrin Bolte, Nicole Gruenheit, Gregor Felsner, Maik S. Sommer, Uwe G. Maier, Franziska Hempel

Research output: Contribution to journal › Article › peer-review

Abstract

At first glance the three eukaryotic protein translocation machineries - the ER-associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre-protein translocator of complex plastids - appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre-existing components as an effective evolutionary driving force. © 2011 WILEY Periodicals, Inc.

Original language	English
Pages (from-to)	368-376
Number of pages	8
Journal	BioEssays
Volume	33
Issue number	5
DOIs	https://doi.org/10.1002/bies.201100007
Publication status	Published - May 2011

Keywords

ERAD
Evolution of protein translocation
Peroxisomal importomer
Secondary plastid
SELMA

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10.1002/bies.201100007

http://www.ncbi.nlm.nih.gov/pubmed/21425305

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AU - Bolte, Kathrin

AU - Gruenheit, Nicole

AU - Felsner, Gregor

AU - Sommer, Maik S.

AU - Maier, Uwe G.

AU - Hempel, Franziska

PY - 2011/5

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AB - At first glance the three eukaryotic protein translocation machineries - the ER-associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre-protein translocator of complex plastids - appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre-existing components as an effective evolutionary driving force. © 2011 WILEY Periodicals, Inc.

KW - ERAD

KW - Evolution of protein translocation

KW - Peroxisomal importomer

KW - Secondary plastid

KW - SELMA

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ER -

Making new out of old: Recycling and modification of an ancient protein translocation system during eukaryotic evolution

Abstract

Keywords

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