Malaria is not responsible for the selection of TCR β-subunit variable gene haplotypes in The Gambia

Ian J. Donaldson; Jahan Shefta; Adrian V. Hill; Arthur W. Boylston

doi:10.1007/s00251-001-0407-7

Malaria is not responsible for the selection of TCR β-subunit variable gene haplotypes in The Gambia

Ian J. Donaldson, Jahan Shefta, Adrian V. Hill, Arthur W. Boylston

Research output: Contribution to journal › Article › peer-review

Abstract

Previous work has shown that a single haplotype of the T-cell antigen receptor β-subunit (TCRB) locus is predominant in African populations. This is likely to be due to selection pressure for gene(s) that protect children against disease. This study has tested the hypothesis that malaria is the responsible selection pressure, due to its impact on child mortality. The haplotypes of BV8S3, BV2S1, BV15S1, and BV3S1 were determined in children suffering from severe malaria and unaffected adult controls. No significant difference between cases and controls was shown for any of the haplotypes studied. In addition, an insertion/deletion (INDEL) haplotype in the 5′ region of the TCRB locus was investigated. Again no differences between the two groups were detected. Therefore, the evidence suggests that malaria is not responsible for haplotype selection in The Gambia.

Original language	English
Pages (from-to)	894-899
Number of pages	5
Journal	Immunogenetics
Volume	53
Issue number	10-11
DOIs	https://doi.org/10.1007/s00251-001-0407-7
Publication status	Published - 2002

Keywords

Case-control
Haplotypes
Malaria
Selection
T-cell antigen receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00251-001-0407-7

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title = "Malaria is not responsible for the selection of TCR β-subunit variable gene haplotypes in The Gambia",

abstract = "Previous work has shown that a single haplotype of the T-cell antigen receptor β-subunit (TCRB) locus is predominant in African populations. This is likely to be due to selection pressure for gene(s) that protect children against disease. This study has tested the hypothesis that malaria is the responsible selection pressure, due to its impact on child mortality. The haplotypes of BV8S3, BV2S1, BV15S1, and BV3S1 were determined in children suffering from severe malaria and unaffected adult controls. No significant difference between cases and controls was shown for any of the haplotypes studied. In addition, an insertion/deletion (INDEL) haplotype in the 5′ region of the TCRB locus was investigated. Again no differences between the two groups were detected. Therefore, the evidence suggests that malaria is not responsible for haplotype selection in The Gambia.",

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T1 - Malaria is not responsible for the selection of TCR β-subunit variable gene haplotypes in The Gambia

AU - Donaldson, Ian J.

AU - Shefta, Jahan

AU - Hill, Adrian V.

AU - Boylston, Arthur W.

PY - 2002

Y1 - 2002

N2 - Previous work has shown that a single haplotype of the T-cell antigen receptor β-subunit (TCRB) locus is predominant in African populations. This is likely to be due to selection pressure for gene(s) that protect children against disease. This study has tested the hypothesis that malaria is the responsible selection pressure, due to its impact on child mortality. The haplotypes of BV8S3, BV2S1, BV15S1, and BV3S1 were determined in children suffering from severe malaria and unaffected adult controls. No significant difference between cases and controls was shown for any of the haplotypes studied. In addition, an insertion/deletion (INDEL) haplotype in the 5′ region of the TCRB locus was investigated. Again no differences between the two groups were detected. Therefore, the evidence suggests that malaria is not responsible for haplotype selection in The Gambia.

AB - Previous work has shown that a single haplotype of the T-cell antigen receptor β-subunit (TCRB) locus is predominant in African populations. This is likely to be due to selection pressure for gene(s) that protect children against disease. This study has tested the hypothesis that malaria is the responsible selection pressure, due to its impact on child mortality. The haplotypes of BV8S3, BV2S1, BV15S1, and BV3S1 were determined in children suffering from severe malaria and unaffected adult controls. No significant difference between cases and controls was shown for any of the haplotypes studied. In addition, an insertion/deletion (INDEL) haplotype in the 5′ region of the TCRB locus was investigated. Again no differences between the two groups were detected. Therefore, the evidence suggests that malaria is not responsible for haplotype selection in The Gambia.

KW - Case-control

KW - Haplotypes

KW - Malaria

KW - Selection

KW - T-cell antigen receptor

U2 - 10.1007/s00251-001-0407-7

DO - 10.1007/s00251-001-0407-7

M3 - Article

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SN - 0093-7711

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SP - 894

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JO - Immunogenetics

JF - Immunogenetics

IS - 10-11

ER -

Malaria is not responsible for the selection of TCR β-subunit variable gene haplotypes in The Gambia

Abstract

Keywords

UN SDGs

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