Mammalian Sterile20-like kinase 1 and the regulation of apoptosis

P. M. De Souza, M. A. Lindsay

    Research output: Contribution to journalArticlepeer-review


    Mammalian Sterile20-like kinase 1 (Mst1) is a ubiquitously expressed serine/threonine kinase which represents a member of the rapidly expanding family of enzymes related to the yeast Sterile20 kinase. Although the physiological function of Mst1 and its role in intracellular signalling is still unclear, reports to date suggest that Mst1, similar to its yeast homologue, operates in the MAPK (mitogen-activated protein kinase) pathway and, in this capacity, may represent a putative MAPK kinase kinase kinase. Moreover, there is abundant evidence for a role of this enzyme in apoptosis, where not only is it a target for caspases, but may also serve as an activator of these proteases to amplify the apoptotic signalling pathway. This paper reviews the investigations that have led to our current understanding of the mechanisms by which Mst1 may be activated and thereby contribute to apoptosis.
    Original languageEnglish
    Pages (from-to)485-488
    Number of pages3
    JournalBiochemical Society Transactions
    Issue number3
    Publication statusPublished - Jun 2004


    • Apoptosis
    • Caspase
    • Eosinophil
    • Mammalian Sterile20-like kinase
    • Mitogen-activated protein kinase
    • Neutrophil


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