Mammographic density and breast cancer characteristics

Kathy Ren, Elaine Harkness, Caroline Boggis, Soujanya Gadde, Mary Wilson, Yit Lim, Jamie Sargeant, Sigrid Whiteside, Julie Morris, Susan Astley

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The aim of this research is to investigate, in a screening population, the relationship between mammographic density and tumour characteristics including size, invasiveness and mammographic features. Mammograms of 105 women with screen detected breast cancer were analysed; 111 lesions were identified. Volumetric density measurements were obtained using Quanta™ and Volpara™. Histological information was extracted from the screening database and radiological features were assessed by two expert breast radiologists. Statistical analysis was performed using Mann-Whitney U test and Spearman’s rank order correlation. The median percentage density by Volpara™ of women with invasive cancers was significantly higher than those with DCIS (6.5 vs 5.0, p =0.046). Similar results were replicated in the Quantra™ measurements, however the results were not statistically significant (17 vs 16, p = 0.19). Further analysis showed a significant positive association between whole tumour size and volumetric density for invasive lesions. Architectural distortion was the only mammographic feature associated with a significant difference in percentage density.
Original languageEnglish
Title of host publicationBreast Imaging: Lecture Notes in Computer Science 8539
EditorsHiroshi Fujita, T Hara, C Muramatsu
Place of PublicationSwitzerland
PublisherSpringer Nature
Number of pages8
Publication statusPublished - Jun 2014
EventInternational Workshop on Breast Imaging - Gifu, Japan
Duration: 1 Jan 1824 → …


ConferenceInternational Workshop on Breast Imaging
CityGifu, Japan
Period1/01/24 → …


  • screening
  • mammogram
  • cancer
  • breast density
  • DCIS


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