Mammographic Density Over Time in Women With and Without Breast Cancer

Abigail Humphrey; Elaine F. Harkness; Emmanouil Moschidis; Emma Hurley; Philip Foden; Megan Bydder; Mary Wilson; Soujanya Gadde; Anthony Maxwell; Yit Y. Lim; Ursula Beetles; Anthony Howell; D. Gareth Evans; Susan M. Astley

doi:10.1007/978-3-319-41546-8_37

Mammographic Density Over Time in Women With and Without Breast Cancer

Abigail Humphrey, Elaine F. Harkness, Emmanouil Moschidis, Emma Hurley, Philip Foden, Megan Bydder, Mary Wilson, Soujanya Gadde, Anthony Maxwell, Yit Y. Lim, Ursula Beetles, Anthony Howell, D. Gareth Evans, Susan M. Astley

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This study compared mammographic density over time between women who developed breast cancer (cases) and women who did not (controls). Cases had an initial negative mammographic screen and another three years later when cancer was diagnosed. Cases were matched to three controls with two successive negative screens by age, year of mammogram, BMI, parity, menopausal status and HRT use. Mammographic density was measured by VolparaTM. There was a significant reduction in percentage density in the affected breast for cases (5.2 to 4.8 %, p < 0.001) and for the same matched breast in controls (4.9 to 4.5, p < 0.001). Similar results were found for the unaffected breast. After adjusting for density measures at the initial screen, case-control status was only significantly associated with fibroglandular volume in the unaffected breast (adjusted mean 45.8 cm3 in cases, 44.0 cm3 in controls, p = 0.008). The results suggest changes in mammographic density may be less important than initial mammographic density.

Original language	English
Title of host publication	Breast imaging
Subtitle of host publication	13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, proceedings
Editors	Anders Tingberg, Kristina Lång, Pontus Timberg
Publisher	Springer Nature
Pages	291-298
ISBN (Print)	978-3-319-41545-1
DOIs	https://doi.org/10.1007/978-3-319-41546-8_37
Publication status	Published - 2016

Publication series

Name	Lecture Notes in Computer Science
Volume	9699

Keywords

Breast cancer
Mammography
Digital
Breast density
Case-control study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-319-41546-8_37

Cite this

Humphrey, A., Harkness, E. F., Moschidis, E., Hurley, E., Foden, P., Bydder, M., Wilson, M., Gadde, S., Maxwell, A., Lim, Y. Y., Beetles, U., Howell, A., Evans, D. G., & Astley, S. M. (2016). Mammographic Density Over Time in Women With and Without Breast Cancer. In A. Tingberg, K. Lång, & P. Timberg (Eds.), Breast imaging: 13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, proceedings (pp. 291-298). (Lecture Notes in Computer Science; Vol. 9699). Springer Nature. https://doi.org/10.1007/978-3-319-41546-8_37

Humphrey, Abigail ; Harkness, Elaine F. ; Moschidis, Emmanouil et al. / Mammographic Density Over Time in Women With and Without Breast Cancer. Breast imaging: 13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, proceedings. editor / Anders Tingberg ; Kristina Lång ; Pontus Timberg. Springer Nature, 2016. pp. 291-298 (Lecture Notes in Computer Science).

@inproceedings{8c8b7bffe677439a8337bd356758928b,

title = "Mammographic Density Over Time in Women With and Without Breast Cancer",

abstract = "This study compared mammographic density over time between women who developed breast cancer (cases) and women who did not (controls). Cases had an initial negative mammographic screen and another three years later when cancer was diagnosed. Cases were matched to three controls with two successive negative screens by age, year of mammogram, BMI, parity, menopausal status and HRT use. Mammographic density was measured by VolparaTM. There was a significant reduction in percentage density in the affected breast for cases (5.2 to 4.8 %, p < 0.001) and for the same matched breast in controls (4.9 to 4.5, p < 0.001). Similar results were found for the unaffected breast. After adjusting for density measures at the initial screen, case-control status was only significantly associated with fibroglandular volume in the unaffected breast (adjusted mean 45.8 cm3 in cases, 44.0 cm3 in controls, p = 0.008). The results suggest changes in mammographic density may be less important than initial mammographic density.",

keywords = "Breast cancer, Mammography, Digital, Breast density, Case-control study",

author = "Abigail Humphrey and Harkness, {Elaine F.} and Emmanouil Moschidis and Emma Hurley and Philip Foden and Megan Bydder and Mary Wilson and Soujanya Gadde and Anthony Maxwell and Lim, {Yit Y.} and Ursula Beetles and Anthony Howell and Evans, {D. Gareth} and Astley, {Susan M.}",

year = "2016",

doi = "10.1007/978-3-319-41546-8_37",

language = "English",

isbn = "978-3-319-41545-1",

series = "Lecture Notes in Computer Science",

publisher = "Springer Nature",

pages = "291--298",

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booktitle = "Breast imaging",

address = "United States",

}

Humphrey, A, Harkness, EF, Moschidis, E, Hurley, E, Foden, P, Bydder, M, Wilson, M, Gadde, S, Maxwell, A, Lim, YY, Beetles, U, Howell, A , Evans, DG & Astley, SM 2016, Mammographic Density Over Time in Women With and Without Breast Cancer. in A Tingberg, K Lång & P Timberg (eds), Breast imaging: 13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, proceedings. Lecture Notes in Computer Science, vol. 9699, Springer Nature, pp. 291-298. https://doi.org/10.1007/978-3-319-41546-8_37

Mammographic Density Over Time in Women With and Without Breast Cancer. / Humphrey, Abigail; Harkness, Elaine F.; Moschidis, Emmanouil et al.
Breast imaging: 13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, proceedings. ed. / Anders Tingberg; Kristina Lång; Pontus Timberg. Springer Nature, 2016. p. 291-298 (Lecture Notes in Computer Science; Vol. 9699).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Mammographic Density Over Time in Women With and Without Breast Cancer

AU - Humphrey, Abigail

AU - Harkness, Elaine F.

AU - Moschidis, Emmanouil

AU - Hurley, Emma

AU - Foden, Philip

AU - Bydder, Megan

AU - Wilson, Mary

AU - Gadde, Soujanya

AU - Maxwell, Anthony

AU - Lim, Yit Y.

AU - Beetles, Ursula

AU - Howell, Anthony

AU - Evans, D. Gareth

AU - Astley, Susan M.

PY - 2016

Y1 - 2016

N2 - This study compared mammographic density over time between women who developed breast cancer (cases) and women who did not (controls). Cases had an initial negative mammographic screen and another three years later when cancer was diagnosed. Cases were matched to three controls with two successive negative screens by age, year of mammogram, BMI, parity, menopausal status and HRT use. Mammographic density was measured by VolparaTM. There was a significant reduction in percentage density in the affected breast for cases (5.2 to 4.8 %, p < 0.001) and for the same matched breast in controls (4.9 to 4.5, p < 0.001). Similar results were found for the unaffected breast. After adjusting for density measures at the initial screen, case-control status was only significantly associated with fibroglandular volume in the unaffected breast (adjusted mean 45.8 cm3 in cases, 44.0 cm3 in controls, p = 0.008). The results suggest changes in mammographic density may be less important than initial mammographic density.

AB - This study compared mammographic density over time between women who developed breast cancer (cases) and women who did not (controls). Cases had an initial negative mammographic screen and another three years later when cancer was diagnosed. Cases were matched to three controls with two successive negative screens by age, year of mammogram, BMI, parity, menopausal status and HRT use. Mammographic density was measured by VolparaTM. There was a significant reduction in percentage density in the affected breast for cases (5.2 to 4.8 %, p < 0.001) and for the same matched breast in controls (4.9 to 4.5, p < 0.001). Similar results were found for the unaffected breast. After adjusting for density measures at the initial screen, case-control status was only significantly associated with fibroglandular volume in the unaffected breast (adjusted mean 45.8 cm3 in cases, 44.0 cm3 in controls, p = 0.008). The results suggest changes in mammographic density may be less important than initial mammographic density.

KW - Breast cancer

KW - Mammography

KW - Digital

KW - Breast density

KW - Case-control study

U2 - 10.1007/978-3-319-41546-8_37

DO - 10.1007/978-3-319-41546-8_37

M3 - Conference contribution

SN - 978-3-319-41545-1

T3 - Lecture Notes in Computer Science

SP - 291

EP - 298

BT - Breast imaging

A2 - Tingberg, Anders

A2 - Lång, Kristina

A2 - Timberg, Pontus

PB - Springer Nature

ER -

Humphrey A, Harkness EF, Moschidis E, Hurley E, Foden P, Bydder M et al. Mammographic Density Over Time in Women With and Without Breast Cancer. In Tingberg A, Lång K, Timberg P, editors, Breast imaging: 13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, proceedings. Springer Nature. 2016. p. 291-298. (Lecture Notes in Computer Science). doi: 10.1007/978-3-319-41546-8_37

Mammographic Density Over Time in Women With and Without Breast Cancer

Abstract

Publication series

Keywords

UN SDGs

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