Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015

S Gillessen; A Omlin; G Attard; J S de Bono; E Efstathiou; K Fizazi; S Halabi; P S Nelson; O Sartor; M R Smith; H R Soule; H Akaza; T M Beer; H Beltran; A M Chinnaiyan; G Daugaard; I D Davis; M De Santis; C G Drake; R A Eeles; S Fanti; M E Gleave; A Heidenreich; M Hussain; N D James; F E Lecouvet; C J Logothetis; K Mastris; S Nilsson; W K Oh; D Olmos; A R Padhani; C Parker; M A Rubin; J A Schalken; H I Scher; A Sella; N D Shore; E J Small; C N Sternberg; H Suzuki; C J Sweeney; I F Tannock; B Tombal

doi:10.1093/annonc/mdv257

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015

S Gillessen, A Omlin, G Attard, J S de Bono, E Efstathiou, K Fizazi, S Halabi, P S Nelson, O Sartor, M R Smith, H R Soule, H Akaza, T M Beer, H Beltran, A M Chinnaiyan, G Daugaard, I D Davis, M De Santis, C G Drake, R A EelesS Fanti, M E Gleave, A Heidenreich, M Hussain, N D James, F E Lecouvet, C J Logothetis, K Mastris, S Nilsson, W K Oh, D Olmos, A R Padhani, C Parker, M A Rubin, J A Schalken, H I Scher, A Sella, N D Shore, E J Small, C N Sternberg, H Suzuki, C J Sweeney, I F Tannock, B Tombal

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged.

Original language	English
Pages (from-to)	1589-1604
Number of pages	16
Journal	Annals of oncology : official journal of the European Society for Medical Oncology
Volume	26
Issue number	8
DOIs	https://doi.org/10.1093/annonc/mdv257
Publication status	Published - Aug 2015

Keywords

Adenocarcinoma/pathology
Androgen Antagonists/therapeutic use
Antineoplastic Agents/therapeutic use
Antineoplastic Agents, Hormonal/therapeutic use
Bone Density Conservation Agents/therapeutic use
Docetaxel
Humans
Male
Orchiectomy
Practice Guidelines as Topic
Prostatectomy
Prostatic Neoplasms/pathology
Prostatic Neoplasms, Castration-Resistant/pathology
Radiotherapy, Adjuvant
Taxoids/therapeutic use

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/annonc/mdv257

Cite this

Gillessen, S., Omlin, A., Attard, G., de Bono, J. S., Efstathiou, E., Fizazi, K., Halabi, S., Nelson, P. S., Sartor, O., Smith, M. R., Soule, H. R., Akaza, H., Beer, T. M., Beltran, H., Chinnaiyan, A. M., Daugaard, G., Davis, I. D., De Santis, M., Drake, C. G., ... Tombal, B. (2015). Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. Annals of oncology : official journal of the European Society for Medical Oncology, 26(8), 1589-1604. https://doi.org/10.1093/annonc/mdv257

@article{6dd0ce2f6ddf42a09e6240f83a463c48,

title = "Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015",

abstract = "The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-na{\"i}ve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged. ",

keywords = "Adenocarcinoma/pathology, Androgen Antagonists/therapeutic use, Antineoplastic Agents/therapeutic use, Antineoplastic Agents, Hormonal/therapeutic use, Bone Density Conservation Agents/therapeutic use, Docetaxel, Humans, Male, Orchiectomy, Practice Guidelines as Topic, Prostatectomy, Prostatic Neoplasms/pathology, Prostatic Neoplasms, Castration-Resistant/pathology, Radiotherapy, Adjuvant, Taxoids/therapeutic use",

author = "S Gillessen and A Omlin and G Attard and \{de Bono\}, \{J S\} and E Efstathiou and K Fizazi and S Halabi and Nelson, \{P S\} and O Sartor and Smith, \{M R\} and Soule, \{H R\} and H Akaza and Beer, \{T M\} and H Beltran and Chinnaiyan, \{A M\} and G Daugaard and Davis, \{I D\} and \{De Santis\}, M and Drake, \{C G\} and Eeles, \{R A\} and S Fanti and Gleave, \{M E\} and A Heidenreich and M Hussain and James, \{N D\} and Lecouvet, \{F E\} and Logothetis, \{C J\} and K Mastris and S Nilsson and Oh, \{W K\} and D Olmos and Padhani, \{A R\} and C Parker and Rubin, \{M A\} and Schalken, \{J A\} and Scher, \{H I\} and A Sella and Shore, \{N D\} and Small, \{E J\} and Sternberg, \{C N\} and H Suzuki and Sweeney, \{C J\} and Tannock, \{I F\} and B Tombal",

note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology.",

year = "2015",

month = aug,

doi = "10.1093/annonc/mdv257",

language = "English",

volume = "26",

pages = "1589--1604",

journal = "Annals of oncology : official journal of the European Society for Medical Oncology",

issn = "0923-7534",

publisher = "Elsevier BV",

number = "8",

}

Gillessen, S, Omlin, A, Attard, G, de Bono, JS, Efstathiou, E, Fizazi, K, Halabi, S, Nelson, PS, Sartor, O, Smith, MR, Soule, HR, Akaza, H, Beer, TM, Beltran, H, Chinnaiyan, AM, Daugaard, G, Davis, ID, De Santis, M, Drake, CG, Eeles, RA, Fanti, S, Gleave, ME, Heidenreich, A, Hussain, M, James, ND, Lecouvet, FE, Logothetis, CJ, Mastris, K, Nilsson, S, Oh, WK, Olmos, D, Padhani, AR, Parker, C, Rubin, MA, Schalken, JA, Scher, HI, Sella, A, Shore, ND, Small, EJ, Sternberg, CN, Suzuki, H, Sweeney, CJ, Tannock, IF & Tombal, B 2015, 'Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015', Annals of oncology : official journal of the European Society for Medical Oncology, vol. 26, no. 8, pp. 1589-1604. https://doi.org/10.1093/annonc/mdv257

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. / Gillessen, S; Omlin, A; Attard, G et al.
In: Annals of oncology : official journal of the European Society for Medical Oncology, Vol. 26, No. 8, 08.2015, p. 1589-1604.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Management of patients with advanced prostate cancer

T2 - recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015

AU - Gillessen, S

AU - Omlin, A

AU - Attard, G

AU - de Bono, J S

AU - Efstathiou, E

AU - Fizazi, K

AU - Halabi, S

AU - Nelson, P S

AU - Sartor, O

AU - Smith, M R

AU - Soule, H R

AU - Akaza, H

AU - Beer, T M

AU - Beltran, H

AU - Chinnaiyan, A M

AU - Daugaard, G

AU - Davis, I D

AU - De Santis, M

AU - Drake, C G

AU - Eeles, R A

AU - Fanti, S

AU - Gleave, M E

AU - Heidenreich, A

AU - Hussain, M

AU - James, N D

AU - Lecouvet, F E

AU - Logothetis, C J

AU - Mastris, K

AU - Nilsson, S

AU - Oh, W K

AU - Olmos, D

AU - Padhani, A R

AU - Parker, C

AU - Rubin, M A

AU - Schalken, J A

AU - Scher, H I

AU - Sella, A

AU - Shore, N D

AU - Small, E J

AU - Sternberg, C N

AU - Suzuki, H

AU - Sweeney, C J

AU - Tannock, I F

AU - Tombal, B

PY - 2015/8

Y1 - 2015/8

N2 - The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged.

AB - The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged.

KW - Adenocarcinoma/pathology

KW - Androgen Antagonists/therapeutic use

KW - Antineoplastic Agents/therapeutic use

KW - Antineoplastic Agents, Hormonal/therapeutic use

KW - Bone Density Conservation Agents/therapeutic use

KW - Docetaxel

KW - Humans

KW - Male

KW - Orchiectomy

KW - Practice Guidelines as Topic

KW - Prostatectomy

KW - Prostatic Neoplasms/pathology

KW - Prostatic Neoplasms, Castration-Resistant/pathology

KW - Radiotherapy, Adjuvant

KW - Taxoids/therapeutic use

UR - https://www.scopus.com/pages/publications/84940469697

U2 - 10.1093/annonc/mdv257

DO - 10.1093/annonc/mdv257

M3 - Article

C2 - 26041764

SN - 0923-7534

VL - 26

SP - 1589

EP - 1604

JO - Annals of oncology : official journal of the European Society for Medical Oncology

JF - Annals of oncology : official journal of the European Society for Medical Oncology

IS - 8

ER -

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

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