Mannose-binding protein gene polymorphism in systemic lupus erythematosus

Eric J. Davies; Neil Snowden; M. Chantal Hillarby; David Carthy; David M. Grennan; Wendy Thomson; William E R Ollier

doi:10.1002/art.1780380117

Mannose-binding protein gene polymorphism in systemic lupus erythematosus

Eric J. Davies, Neil Snowden, M. Chantal Hillarby, David Carthy, David M. Grennan, Wendy Thomson, William E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE). Methods. MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls. Results. The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3). Conclusion. Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.

Original language	English
Pages (from-to)	110-114
Number of pages	4
Journal	Arthritis Care & Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1002/art.1780380117
Publication status	Published - Jan 1995

Keywords

ACADEMIC JOURNAL PAPERS
ORIGINAL ARTICLES

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10.1002/art.1780380117

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@article{319ab8a99b3b431ca3a291f2878eaaa5,

title = "Mannose-binding protein gene polymorphism in systemic lupus erythematosus",

abstract = "Objective. To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE). Methods. MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls. Results. The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3). Conclusion. Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.",

keywords = "ACADEMIC JOURNAL PAPERS, ORIGINAL ARTICLES",

author = "Davies, {Eric J.} and Neil Snowden and Hillarby, {M. Chantal} and David Carthy and Grennan, {David M.} and Wendy Thomson and Ollier, {William E R}",

note = "UI - 95118384 LA - eng RN - 0 (Carrier Proteins) RN - 0 (mannose-binding proteins) RN - 9007-36-7 (Complement) PT - Journal Article DA - 19950207 IS - 0004-3591 SB - AIM SB - IM CY - UNITED STATES",

year = "1995",

month = jan,

doi = "10.1002/art.1780380117",

language = "English",

volume = "38",

pages = "110--114",

journal = "Arthritis Care & Research",

issn = "2151-464X",

publisher = "John Wiley & Sons Ltd",

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TY - JOUR

T1 - Mannose-binding protein gene polymorphism in systemic lupus erythematosus

AU - Davies, Eric J.

AU - Snowden, Neil

AU - Hillarby, M. Chantal

AU - Carthy, David

AU - Grennan, David M.

AU - Thomson, Wendy

AU - Ollier, William E R

N1 - UI - 95118384 LA - eng RN - 0 (Carrier Proteins) RN - 0 (mannose-binding proteins) RN - 9007-36-7 (Complement) PT - Journal Article DA - 19950207 IS - 0004-3591 SB - AIM SB - IM CY - UNITED STATES

PY - 1995/1

Y1 - 1995/1

N2 - Objective. To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE). Methods. MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls. Results. The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3). Conclusion. Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.

AB - Objective. To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE). Methods. MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls. Results. The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3). Conclusion. Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.

KW - ACADEMIC JOURNAL PAPERS

KW - ORIGINAL ARTICLES

U2 - 10.1002/art.1780380117

DO - 10.1002/art.1780380117

M3 - Article

SN - 2151-464X

VL - 38

SP - 110

EP - 114

JO - Arthritis Care & Research

JF - Arthritis Care & Research

IS - 1

ER -

Mannose-binding protein gene polymorphism in systemic lupus erythematosus

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