Mapping metabolic brain activation during human volitional swallowing: A positron emission tomography study using [18F]fluorodeoxyglucose

Mary Louise Harris, Peter Julyan, Bhavna Kulkarni, David Gow, Anthony Hobson, David Hastings, Jamal Zweit, Shaheen Hamdy

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have previously shown that labelled water positron emission tomography (H215O PET) can be used to identify regional cerebral blood flow (rCBF) changes in the human brain during volitional swallowing. (18F) fluorodeoxyglucose (FDG PET), by comparison, uses a glucose analogue to quantitatively measure regional cerebral glucose metabolism (rCMRglc) rather than rCBF. The main advantage of FDG PET is improved spatial resolution, and because of its pharmacodynamic properties, activation can be performed external to the scanner, allowing subjects to assume more physiologic positions. We therefore conducted a study of the brain's metabolic response while swallowing in the erect seated position, using FDG PET. Eight healthy male volunteers were studied with a randomised 2 scan paradigm of rest or water swallowing at 20-second intervals for 30 minutes. Data were analysed with SPM99 using multisubject conditions and covariates design. During swallowing, analysis identified increased rCMRglc (P
    Original languageEnglish
    Pages (from-to)520-526
    Number of pages6
    JournalJournal of Cerebral Blood Flow and Metabolism
    Volume25
    Issue number4
    DOIs
    Publication statusPublished - Apr 2005

    Keywords

    • Brain activation
    • Cerebral glucose metabolism
    • FDG PET
    • Volitional swallowing

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