Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker

J. Bellingham; K. Gregory-Evans; C. Y. Gregory-Evans

Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker

J. Bellingham, K. Gregory-Evans, C. Y. Gregory-Evans

Research output: Contribution to journal › Article › peer-review

Abstract

We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.

Original language	English
Pages (from-to)	231-234
Number of pages	3
Journal	Annals of Human Genetics
Volume	62
Issue number	3
Publication status	Published - May 1998

Keywords

Alleles
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 19
DNA, Complementary
genetics: DNA-Binding Proteins
Gene Frequency
Genetic Markers
Humans
Interferon Regulatory Factor-3
Molecular Sequence Data
Polymorphism, Genetic
genetics: Transcription Factors

Cite this

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title = "Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker",

abstract = "We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.",

keywords = "Alleles, Amino Acid Sequence, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 19, DNA, Complementary, genetics: DNA-Binding Proteins, Gene Frequency, Genetic Markers, Humans, Interferon Regulatory Factor-3, Molecular Sequence Data, Polymorphism, Genetic, genetics: Transcription Factors",

author = "J. Bellingham and K. Gregory-Evans and Gregory-Evans, {C. Y.}",

year = "1998",

month = may,

language = "English",

volume = "62",

pages = "231--234",

journal = "Annals of Human Genetics",

issn = "0003-4800",

publisher = "John Wiley & Sons Ltd",

number = "3",

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TY - JOUR

T1 - Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker

AU - Bellingham, J.

AU - Gregory-Evans, K.

AU - Gregory-Evans, C. Y.

PY - 1998/5

Y1 - 1998/5

N2 - We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.

AB - We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.

KW - Alleles

KW - Amino Acid Sequence

KW - Base Sequence

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 19

KW - DNA, Complementary

KW - genetics: DNA-Binding Proteins

KW - Gene Frequency

KW - Genetic Markers

KW - Humans

KW - Interferon Regulatory Factor-3

KW - Molecular Sequence Data

KW - Polymorphism, Genetic

KW - genetics: Transcription Factors

M3 - Article

SN - 0003-4800

VL - 62

SP - 231

EP - 234

JO - Annals of Human Genetics

JF - Annals of Human Genetics

IS - 3

ER -

Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker

Abstract

Keywords

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