Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India

A. H. Heald; S. G. Anderson; A. Vyas; K. Siddals; J. Patel; A. P. Yates; D. Bhatnagar; D. Prabhakaran; E. Hughes; A. Rudenski; P. Durrington; J. M. Gibson; J. K. Cruickshank

doi:10.1007/s00125-005-1871-7

Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India

A. H. Heald
, S. G. Anderson
, A. Vyas
, K. Siddals
, J. Patel
, A. P. Yates
, D. Bhatnagar
, D. Prabhakaran
, E. Hughes
, A. Rudenski
, P. Durrington
, J. M. Gibson
, J. K. Cruickshank

Research output: Contribution to journal › Article › peer-review

Abstract

Aims/hypotheses: We previously reported independent links between the IGF system and the development of impaired glucose tolerance and cardiovascular risk. This study tests the hypothesis that the lifestyle change which accompanies population migration, with attendant increases in cardiovascular risk, is reflected by changes in the IGF system. Materials and methods: We compared a specific Gujarati community in Sandwell, UK (n=205), with people still resident in the same villages of origin near Navsari, India (n=246). We performed anthropometry and measured fasting plasma insulin, IGF-I, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3. Results: Daily calorie intake, BMI and WHR were significantly higher in UK Gujaratis than in Indian Gujaratis. IGFBP-1 was significantly lower in UK migrants (mean 29.5 [95% CI 25.9-33.0] vs 56.5 [50.6-62.5]μg/l; F=48.4, p

Original language	English
Pages (from-to)	1756-1765
Number of pages	9
Journal	Diabetologia
Volume	48
Issue number	9
DOIs	https://doi.org/10.1007/s00125-005-1871-7
Publication status	Published - Sept 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

IGF
IGFBP-1
IGFBP-3
Insulin resistance
Lifestyle
Migration

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10.1007/s00125-005-1871-7

Cite this

Heald, A. H., Anderson, S. G., Vyas, A., Siddals, K., Patel, J., Yates, A. P., Bhatnagar, D., Prabhakaran, D., Hughes, E., Rudenski, A., Durrington, P., Gibson, J. M., & Cruickshank, J. K. (2005). Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India. Diabetologia, 48(9), 1756-1765. https://doi.org/10.1007/s00125-005-1871-7

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title = "Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India",

abstract = "Aims/hypotheses: We previously reported independent links between the IGF system and the development of impaired glucose tolerance and cardiovascular risk. This study tests the hypothesis that the lifestyle change which accompanies population migration, with attendant increases in cardiovascular risk, is reflected by changes in the IGF system. Materials and methods: We compared a specific Gujarati community in Sandwell, UK (n=205), with people still resident in the same villages of origin near Navsari, India (n=246). We performed anthropometry and measured fasting plasma insulin, IGF-I, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3. Results: Daily calorie intake, BMI and WHR were significantly higher in UK Gujaratis than in Indian Gujaratis. IGFBP-1 was significantly lower in UK migrants (mean 29.5 [95\% CI 25.9-33.0] vs 56.5 [50.6-62.5]μg/l; F=48.4, p",

keywords = "IGF, IGFBP-1, IGFBP-3, Insulin resistance, Lifestyle, Migration",

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Heald, AH, Anderson, SG, Vyas, A, Siddals, K, Patel, J, Yates, AP, Bhatnagar, D, Prabhakaran, D, Hughes, E, Rudenski, A, Durrington, P, Gibson, JM & Cruickshank, JK 2005, 'Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India', Diabetologia, vol. 48, no. 9, pp. 1756-1765. https://doi.org/10.1007/s00125-005-1871-7

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AU - Heald, A. H.

AU - Anderson, S. G.

AU - Vyas, A.

AU - Siddals, K.

AU - Patel, J.

AU - Yates, A. P.

AU - Bhatnagar, D.

AU - Prabhakaran, D.

AU - Hughes, E.

AU - Rudenski, A.

AU - Durrington, P.

AU - Gibson, J. M.

AU - Cruickshank, J. K.

PY - 2005/9

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N2 - Aims/hypotheses: We previously reported independent links between the IGF system and the development of impaired glucose tolerance and cardiovascular risk. This study tests the hypothesis that the lifestyle change which accompanies population migration, with attendant increases in cardiovascular risk, is reflected by changes in the IGF system. Materials and methods: We compared a specific Gujarati community in Sandwell, UK (n=205), with people still resident in the same villages of origin near Navsari, India (n=246). We performed anthropometry and measured fasting plasma insulin, IGF-I, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3. Results: Daily calorie intake, BMI and WHR were significantly higher in UK Gujaratis than in Indian Gujaratis. IGFBP-1 was significantly lower in UK migrants (mean 29.5 [95% CI 25.9-33.0] vs 56.5 [50.6-62.5]μg/l; F=48.4, p

AB - Aims/hypotheses: We previously reported independent links between the IGF system and the development of impaired glucose tolerance and cardiovascular risk. This study tests the hypothesis that the lifestyle change which accompanies population migration, with attendant increases in cardiovascular risk, is reflected by changes in the IGF system. Materials and methods: We compared a specific Gujarati community in Sandwell, UK (n=205), with people still resident in the same villages of origin near Navsari, India (n=246). We performed anthropometry and measured fasting plasma insulin, IGF-I, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3. Results: Daily calorie intake, BMI and WHR were significantly higher in UK Gujaratis than in Indian Gujaratis. IGFBP-1 was significantly lower in UK migrants (mean 29.5 [95% CI 25.9-33.0] vs 56.5 [50.6-62.5]μg/l; F=48.4, p

KW - IGF

KW - IGFBP-1

KW - IGFBP-3

KW - Insulin resistance

KW - Lifestyle

KW - Migration

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DO - 10.1007/s00125-005-1871-7

M3 - Article

SN - 1432-0428

VL - 48

SP - 1756

EP - 1765

JO - Diabetologia

JF - Diabetologia

IS - 9

ER -

Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India

Abstract

UN SDGs

Keywords

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