Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

Anne Dudeck, Jan Dudeck, Julia Scholten, Anke Petzold, Sangeetha Surianarayanan, Anja Köhler, Katrin Peschke, David Vöhringer, Claudia Waskow, Thomas Krieg, Werner Müller, Ari Waisman, Karin Hartmann, Matthias Gunzer, Axel Roers

    Research output: Contribution to journalArticlepeer-review


    A prominent feature of sensitizing environmental compounds that cause allergic contact dermatitis is the rapid induction of an innate inflammatory response that seems to provide danger signals for efficient T cell priming. We generated mouse models of mast cell deficiency, mast cell-specific gene inactivation, and mast cell reporter mice for intravital imaging and showed that these adjuvant effects of contact allergens are mediated by mast cells and histamine. Mast cell deficiency resulted in impaired emigration of skin DCs to the lymph node and contact hypersensitivity was dramatically reduced in the absence of mast cells. In addition, mast cell-specific inactivation of the Il10 gene did not reveal any role for mast cell-derived IL-10 in the regulation of contact allergy. Collectively, we demonstrate that mast cells are essential promoters of contact hypersensitivity, thereby highlighting their potential to promote immune responses to antigens entering via the skin. © 2011 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)973-984
    Number of pages11
    Issue number6
    Publication statusPublished - 24 Jun 2011


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