Mast cells in the pathogenesis of chronic back pain: A hypothesis

Anthony J. Freemont; Maria Jeziorska; Judith A. Hoyland; Paul Rooney; Shant Kumar

doi:10.1002/path.1107

Mast cells in the pathogenesis of chronic back pain: A hypothesis

Anthony J. Freemont, Maria Jeziorska, Judith A. Hoyland, Paul Rooney, Shant Kumar

Research output: Contribution to journal › Article › peer-review

Abstract

The pathophysiology of chronic low back pain is poorly understood, mainly because it is difficult to study experimentally or objectively. Recently it has been found that there is a relationship between neovascularization and innervation of the usually avascular and aneural intervertebral disc at the sites of discogenic pain. These data, together with the recognized involvement of mast cells in tissue repair, in the induction of angiogenesis, and in the production of and response to neurotrophic stimuli such as nerve growth factor, has suggested the hypothesis that mast cells may have a causative role in chronic low back pain. If so, the mast cell may represent an attractive therapeutic target. Copyright © 2002 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	281-285
Number of pages	4
Journal	Journal of Pathology
Volume	197
Issue number	3
DOIs	https://doi.org/10.1002/path.1107
Publication status	Published - 2002

Keywords

Angiogenesis
Chronic low back pain
Intervertebral disc
Mast cells
Nerve fibres
Nerve growth factor

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10.1002/path.1107

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title = "Mast cells in the pathogenesis of chronic back pain: A hypothesis",

abstract = "The pathophysiology of chronic low back pain is poorly understood, mainly because it is difficult to study experimentally or objectively. Recently it has been found that there is a relationship between neovascularization and innervation of the usually avascular and aneural intervertebral disc at the sites of discogenic pain. These data, together with the recognized involvement of mast cells in tissue repair, in the induction of angiogenesis, and in the production of and response to neurotrophic stimuli such as nerve growth factor, has suggested the hypothesis that mast cells may have a causative role in chronic low back pain. If so, the mast cell may represent an attractive therapeutic target. Copyright {\textcopyright} 2002 John Wiley & Sons, Ltd.",

keywords = "Angiogenesis, Chronic low back pain, Intervertebral disc, Mast cells, Nerve fibres, Nerve growth factor",

author = "Freemont, {Anthony J.} and Maria Jeziorska and Hoyland, {Judith A.} and Paul Rooney and Shant Kumar",

year = "2002",

doi = "10.1002/path.1107",

language = "English",

volume = "197",

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journal = "Journal of Pathology",

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AU - Freemont, Anthony J.

AU - Jeziorska, Maria

AU - Hoyland, Judith A.

AU - Rooney, Paul

AU - Kumar, Shant

PY - 2002

Y1 - 2002

N2 - The pathophysiology of chronic low back pain is poorly understood, mainly because it is difficult to study experimentally or objectively. Recently it has been found that there is a relationship between neovascularization and innervation of the usually avascular and aneural intervertebral disc at the sites of discogenic pain. These data, together with the recognized involvement of mast cells in tissue repair, in the induction of angiogenesis, and in the production of and response to neurotrophic stimuli such as nerve growth factor, has suggested the hypothesis that mast cells may have a causative role in chronic low back pain. If so, the mast cell may represent an attractive therapeutic target. Copyright © 2002 John Wiley & Sons, Ltd.

AB - The pathophysiology of chronic low back pain is poorly understood, mainly because it is difficult to study experimentally or objectively. Recently it has been found that there is a relationship between neovascularization and innervation of the usually avascular and aneural intervertebral disc at the sites of discogenic pain. These data, together with the recognized involvement of mast cells in tissue repair, in the induction of angiogenesis, and in the production of and response to neurotrophic stimuli such as nerve growth factor, has suggested the hypothesis that mast cells may have a causative role in chronic low back pain. If so, the mast cell may represent an attractive therapeutic target. Copyright © 2002 John Wiley & Sons, Ltd.

KW - Angiogenesis

KW - Chronic low back pain

KW - Intervertebral disc

KW - Mast cells

KW - Nerve fibres

KW - Nerve growth factor

U2 - 10.1002/path.1107

DO - 10.1002/path.1107

M3 - Article

SN - 0022-3417

VL - 197

SP - 281

EP - 285

JO - Journal of Pathology

JF - Journal of Pathology

IS - 3

ER -

Mast cells in the pathogenesis of chronic back pain: A hypothesis

Abstract

Keywords

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