Matched Molecular Pair Analysis

A. G. Leach; I. Lukac; J. M. Zarnecka; A. G. Dossetter; E. J. Griffen

doi:10.1016/B978-0-12-409547-2.12347-9

Matched Molecular Pair Analysis

A. G. Leach, I. Lukac, J. M. Zarnecka, A. G. Dossetter, E. J. Griffen

Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The aim of this article is to highlight the areas in which matched molecular pair analysis has progressed in the last decade and new directions and challenges that are currently being addressed.

Original language	English
Title of host publication	Comprehensive Medicinal Chemistry III
Publisher	Elsevier BV
Pages	221-252
Number of pages	32
Volume	3
ISBN (Electronic)	9780128032008
ISBN (Print)	9780128032015
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.12347-9
Publication status	Published - 3 Jun 2017

Keywords

Activity cliffs
Algorithms
Bioisosteres
Chemoinformatics
Drug design
Drug discovery
Lead optimization
Matched molecular pair analysis (MMPA)
Matched molecular series
Medicinal chemistry
Quantitative structure-activity relationships (QSAR)
Structure-activity relationships

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10.1016/B978-0-12-409547-2.12347-9

Cite this

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title = "Matched Molecular Pair Analysis",

abstract = "The aim of this article is to highlight the areas in which matched molecular pair analysis has progressed in the last decade and new directions and challenges that are currently being addressed.",

keywords = "Activity cliffs, Algorithms, Bioisosteres, Chemoinformatics, Drug design, Drug discovery, Lead optimization, Matched molecular pair analysis (MMPA), Matched molecular series, Medicinal chemistry, Quantitative structure-activity relationships (QSAR), Structure-activity relationships",

author = "Leach, {A. G.} and I. Lukac and Zarnecka, {J. M.} and Dossetter, {A. G.} and Griffen, {E. J.}",

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T1 - Matched Molecular Pair Analysis

AU - Leach, A. G.

AU - Lukac, I.

AU - Zarnecka, J. M.

AU - Dossetter, A. G.

AU - Griffen, E. J.

PY - 2017/6/3

Y1 - 2017/6/3

N2 - The aim of this article is to highlight the areas in which matched molecular pair analysis has progressed in the last decade and new directions and challenges that are currently being addressed.

AB - The aim of this article is to highlight the areas in which matched molecular pair analysis has progressed in the last decade and new directions and challenges that are currently being addressed.

KW - Activity cliffs

KW - Algorithms

KW - Bioisosteres

KW - Chemoinformatics

KW - Drug design

KW - Drug discovery

KW - Lead optimization

KW - Matched molecular pair analysis (MMPA)

KW - Matched molecular series

KW - Medicinal chemistry

KW - Quantitative structure-activity relationships (QSAR)

KW - Structure-activity relationships

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M3 - Chapter

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SN - 9780128032015

VL - 3

SP - 221

EP - 252

BT - Comprehensive Medicinal Chemistry III

PB - Elsevier BV

ER -

Matched Molecular Pair Analysis

Abstract

Keywords

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