Maternal body mass index and congenital anomaly risk: a cohort study.

J Rankin; P W G Tennant; K J Stothard; M Bythell; C D Summerbell; R Bell

doi:10.1038/ijo.2010.66

Maternal body mass index and congenital anomaly risk: a cohort study.

J Rankin
, P W G Tennant
, K J Stothard
, M Bythell
, C D Summerbell
, R Bell

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To investigate the association between maternal body mass index (BMI) and major, structural congenital anomalies. DESIGN: Cohort study using prospectively collected data. METHODS: Data on all singleton pregnancies booked at five maternity units in the north of England between 01 January 2003 and 31 December 2005 and data on congenital anomalies notified to the Northern Congenital Abnormality Survey were linked using key variables. Maternal pre-gestational diabetic status was derived from the Northern Diabetes in Pregnancy Survey. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated by maximum-likelihood logistic regression models, with missing values modelled as explicit categories. RESULTS: There was a total of 41,013 singleton pregnancies during the study period, of which 682 were affected by a structural congenital anomaly, a total prevalence of 166 (95% CI: 154, 179) per 10,000 registered births. Overall, the risk of a congenital anomaly was significantly increased among the maternal underweight (BMI

Original language	English
Journal	International journal of obesity (2005)
Volume	34
Issue number	9
DOIs	https://doi.org/10.1038/ijo.2010.66
Publication status	Published - Sept 2010

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title = "Maternal body mass index and congenital anomaly risk: a cohort study.",

abstract = "OBJECTIVE: To investigate the association between maternal body mass index (BMI) and major, structural congenital anomalies. DESIGN: Cohort study using prospectively collected data. METHODS: Data on all singleton pregnancies booked at five maternity units in the north of England between 01 January 2003 and 31 December 2005 and data on congenital anomalies notified to the Northern Congenital Abnormality Survey were linked using key variables. Maternal pre-gestational diabetic status was derived from the Northern Diabetes in Pregnancy Survey. Adjusted odds ratios (aORs) and 95\% confidence intervals (CIs) were estimated by maximum-likelihood logistic regression models, with missing values modelled as explicit categories. RESULTS: There was a total of 41,013 singleton pregnancies during the study period, of which 682 were affected by a structural congenital anomaly, a total prevalence of 166 (95\% CI: 154, 179) per 10,000 registered births. Overall, the risk of a congenital anomaly was significantly increased among the maternal underweight (BMI",

author = "J Rankin and Tennant, \{P W G\} and Stothard, \{K J\} and M Bythell and Summerbell, \{C D\} and R Bell",

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doi = "10.1038/ijo.2010.66",

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T1 - Maternal body mass index and congenital anomaly risk: a cohort study.

AU - Rankin, J

AU - Tennant, P W G

AU - Stothard, K J

AU - Bythell, M

AU - Summerbell, C D

AU - Bell, R

PY - 2010/9

Y1 - 2010/9

N2 - OBJECTIVE: To investigate the association between maternal body mass index (BMI) and major, structural congenital anomalies. DESIGN: Cohort study using prospectively collected data. METHODS: Data on all singleton pregnancies booked at five maternity units in the north of England between 01 January 2003 and 31 December 2005 and data on congenital anomalies notified to the Northern Congenital Abnormality Survey were linked using key variables. Maternal pre-gestational diabetic status was derived from the Northern Diabetes in Pregnancy Survey. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated by maximum-likelihood logistic regression models, with missing values modelled as explicit categories. RESULTS: There was a total of 41,013 singleton pregnancies during the study period, of which 682 were affected by a structural congenital anomaly, a total prevalence of 166 (95% CI: 154, 179) per 10,000 registered births. Overall, the risk of a congenital anomaly was significantly increased among the maternal underweight (BMI

AB - OBJECTIVE: To investigate the association between maternal body mass index (BMI) and major, structural congenital anomalies. DESIGN: Cohort study using prospectively collected data. METHODS: Data on all singleton pregnancies booked at five maternity units in the north of England between 01 January 2003 and 31 December 2005 and data on congenital anomalies notified to the Northern Congenital Abnormality Survey were linked using key variables. Maternal pre-gestational diabetic status was derived from the Northern Diabetes in Pregnancy Survey. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated by maximum-likelihood logistic regression models, with missing values modelled as explicit categories. RESULTS: There was a total of 41,013 singleton pregnancies during the study period, of which 682 were affected by a structural congenital anomaly, a total prevalence of 166 (95% CI: 154, 179) per 10,000 registered births. Overall, the risk of a congenital anomaly was significantly increased among the maternal underweight (BMI

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DO - 10.1038/ijo.2010.66

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VL - 34

JO - International journal of obesity (2005)

JF - International journal of obesity (2005)

IS - 9

ER -

Maternal body mass index and congenital anomaly risk: a cohort study.

Abstract

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