Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications

Shalem Y. Leemaqz, Gustaaf A. Dekker, Lesley M. McCowan, Louise C. Kenny, Jenny Myers, Nigel A B Simpson, Lucilla Poston, Claire T. Roberts

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Widespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15 ± 1 and 20 ± 1 weeks' gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks' gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45-3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% CI:1.41-3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks' gestation had a greater effect size [adj OR 5.44 (95% CI 2.44-12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern.

    Original languageEnglish
    Pages (from-to)77-86
    Number of pages10
    JournalReproductive toxicology (Elmsford, N.Y.)
    Volume62
    Early online date30 Apr 2016
    DOIs
    Publication statusPublished - Jul 2016

    Keywords

    • BMI
    • Marijuana
    • Pregnancy outcome
    • Smoking
    • Spontaneous preterm birth

    Fingerprint

    Dive into the research topics of 'Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications'. Together they form a unique fingerprint.

    Cite this