Maternal obesity and its effect on placental cell turnover

Lucy Higgins; Tracey A. Mills; Susan L. Greenwood; Elizabeth J. Cowley; Colin P. Sibley; Rebecca L. Jones

doi:10.3109/14767058.2012.760539

Maternal obesity and its effect on placental cell turnover

Lucy Higgins, Tracey A. Mills, Susan L. Greenwood, Elizabeth J. Cowley, Colin P. Sibley, Rebecca L. Jones

Division of Developmental Biology & Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Maternal obesity is a frequent obstetric risk factor, linked with short-and long-term consequences for mother and child, including foetal overgrowth, growth restriction and stillbirth. The mechanisms underlying these pathologies remain unknown but likely involve the placenta. Aims: To study placental cell turnover in relation to maternal body mass index (BMI). Methods: Term placental villous tissue was randomly sampled from 24 pregnancies, with a range of maternal BMI of 19.5-49.6. Immunohistochemistry was performed for human chorionic gonadotropin, Ki67 and M30 and image analysis used to calculate syncytiotrophoblast area and proliferative and apoptotic indices. Results were compared categorically between women of BMI 18.5-24.9 (normal), BMI 30.0-39.9 (obese classes 1and 2) and BMI 40+ (obese class 3) and continuously against BMI; p

Original language	English
Pages (from-to)	783-788
Number of pages	5
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	26
Issue number	8
DOIs	https://doi.org/10.3109/14767058.2012.760539
Publication status	Published - May 2013

Keywords

Adiopokine
Apoptosis
Body mass index
Immunohistochemistry
Pregnancy
Proliferation
Syncytiotrophoblast
Villous

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/14767058.2012.760539

Cite this

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title = "Maternal obesity and its effect on placental cell turnover",

abstract = "Background: Maternal obesity is a frequent obstetric risk factor, linked with short-and long-term consequences for mother and child, including foetal overgrowth, growth restriction and stillbirth. The mechanisms underlying these pathologies remain unknown but likely involve the placenta. Aims: To study placental cell turnover in relation to maternal body mass index (BMI). Methods: Term placental villous tissue was randomly sampled from 24 pregnancies, with a range of maternal BMI of 19.5-49.6. Immunohistochemistry was performed for human chorionic gonadotropin, Ki67 and M30 and image analysis used to calculate syncytiotrophoblast area and proliferative and apoptotic indices. Results were compared categorically between women of BMI 18.5-24.9 (normal), BMI 30.0-39.9 (obese classes 1and 2) and BMI 40+ (obese class 3) and continuously against BMI; p",

keywords = "Adiopokine, Apoptosis, Body mass index, Immunohistochemistry, Pregnancy, Proliferation, Syncytiotrophoblast, Villous",

author = "Lucy Higgins and Mills, {Tracey A.} and Greenwood, {Susan L.} and Cowley, {Elizabeth J.} and Sibley, {Colin P.} and Jones, {Rebecca L.}",

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doi = "10.3109/14767058.2012.760539",

language = "English",

volume = "26",

pages = "783--788",

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TY - JOUR

T1 - Maternal obesity and its effect on placental cell turnover

AU - Higgins, Lucy

AU - Mills, Tracey A.

AU - Greenwood, Susan L.

AU - Cowley, Elizabeth J.

AU - Sibley, Colin P.

AU - Jones, Rebecca L.

PY - 2013/5

Y1 - 2013/5

N2 - Background: Maternal obesity is a frequent obstetric risk factor, linked with short-and long-term consequences for mother and child, including foetal overgrowth, growth restriction and stillbirth. The mechanisms underlying these pathologies remain unknown but likely involve the placenta. Aims: To study placental cell turnover in relation to maternal body mass index (BMI). Methods: Term placental villous tissue was randomly sampled from 24 pregnancies, with a range of maternal BMI of 19.5-49.6. Immunohistochemistry was performed for human chorionic gonadotropin, Ki67 and M30 and image analysis used to calculate syncytiotrophoblast area and proliferative and apoptotic indices. Results were compared categorically between women of BMI 18.5-24.9 (normal), BMI 30.0-39.9 (obese classes 1and 2) and BMI 40+ (obese class 3) and continuously against BMI; p

AB - Background: Maternal obesity is a frequent obstetric risk factor, linked with short-and long-term consequences for mother and child, including foetal overgrowth, growth restriction and stillbirth. The mechanisms underlying these pathologies remain unknown but likely involve the placenta. Aims: To study placental cell turnover in relation to maternal body mass index (BMI). Methods: Term placental villous tissue was randomly sampled from 24 pregnancies, with a range of maternal BMI of 19.5-49.6. Immunohistochemistry was performed for human chorionic gonadotropin, Ki67 and M30 and image analysis used to calculate syncytiotrophoblast area and proliferative and apoptotic indices. Results were compared categorically between women of BMI 18.5-24.9 (normal), BMI 30.0-39.9 (obese classes 1and 2) and BMI 40+ (obese class 3) and continuously against BMI; p

KW - Adiopokine

KW - Apoptosis

KW - Body mass index

KW - Immunohistochemistry

KW - Pregnancy

KW - Proliferation

KW - Syncytiotrophoblast

KW - Villous

U2 - 10.3109/14767058.2012.760539

DO - 10.3109/14767058.2012.760539

M3 - Article

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SN - 1476-7058

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JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

IS - 8

ER -

Maternal obesity and its effect on placental cell turnover

Abstract

Keywords

UN SDGs

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