Maternal perception of reduced fetal movements is associated with altered placental structure and function

Lynne K. Warrander; Gauri Batra; Giovanna Bernatavicius; Susan L. Greenwood; Philip Dutton; Rebecca L. Jones; Colin P. Sibley; Alexander E P Heazell

doi:10.1371/journal.pone.0034851

Maternal perception of reduced fetal movements is associated with altered placental structure and function

Lynne K. Warrander, Gauri Batra, Giovanna Bernatavicius, Susan L. Greenwood, Philip Dutton, Rebecca L. Jones, Colin P. Sibley, Alexander E P Heazell

Division of Developmental Biology & Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM. Objective: To determine whether maternal perception of reduced fetal movements (RFM) is associated with abnormalities in placental structure and function. Design: Placentas were collected from women with RFM after 28 weeks gestation if delivery occurred within 1 week. Women with normal movements served as a control group. Placentas were weighed and photographs taken. Microscopic structure was evaluated by immunohistochemical staining and image analysis. System A amino acid transporter activity was measured as a marker of placental function. Placentas from all pregnancies with RFM (irrespective of outcome) had greater area with signs of infarction (3.5% vs. 0.6%; p

Original language	English
Article number	e34851
Journal	PLoS ONE
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0034851
Publication status	Published - 16 Apr 2012

Keywords

Adolescent
Adult
Amino Acid Transport System A/metabolism
Female
Fetal Growth Retardation/*etiology
*Fetal Movement
Humans
Infant, Newborn
Infant, Small for Gestational Age
Perception
Placenta/blood supply/*pathology/*physiopathology
Pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0034851

Preventing Stillbirth and Improving the Quality of Care After a Baby Dies
Heazell, A. (Participant), Jones, R. (Participant) & Sibley, C. (Participant)
Impact: Health and wellbeing

Cite this

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title = "Maternal perception of reduced fetal movements is associated with altered placental structure and function",

abstract = "Background: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM. Objective: To determine whether maternal perception of reduced fetal movements (RFM) is associated with abnormalities in placental structure and function. Design: Placentas were collected from women with RFM after 28 weeks gestation if delivery occurred within 1 week. Women with normal movements served as a control group. Placentas were weighed and photographs taken. Microscopic structure was evaluated by immunohistochemical staining and image analysis. System A amino acid transporter activity was measured as a marker of placental function. Placentas from all pregnancies with RFM (irrespective of outcome) had greater area with signs of infarction (3.5% vs. 0.6%; p",

keywords = "Adolescent, Adult, Amino Acid Transport System A/metabolism, Female, Fetal Growth Retardation/*etiology, *Fetal Movement, Humans, Infant, Newborn, Infant, Small for Gestational Age, Perception, Placenta/blood supply/*pathology/*physiopathology, Pregnancy",

author = "Warrander, {Lynne K.} and Gauri Batra and Giovanna Bernatavicius and Greenwood, {Susan L.} and Philip Dutton and Jones, {Rebecca L.} and Sibley, {Colin P.} and Heazell, {Alexander E P}",

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AU - Warrander, Lynne K.

AU - Batra, Gauri

AU - Bernatavicius, Giovanna

AU - Greenwood, Susan L.

AU - Dutton, Philip

AU - Jones, Rebecca L.

AU - Sibley, Colin P.

AU - Heazell, Alexander E P

N1 - , Wellcome Trust, United Kingdom

PY - 2012/4/16

Y1 - 2012/4/16

N2 - Background: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM. Objective: To determine whether maternal perception of reduced fetal movements (RFM) is associated with abnormalities in placental structure and function. Design: Placentas were collected from women with RFM after 28 weeks gestation if delivery occurred within 1 week. Women with normal movements served as a control group. Placentas were weighed and photographs taken. Microscopic structure was evaluated by immunohistochemical staining and image analysis. System A amino acid transporter activity was measured as a marker of placental function. Placentas from all pregnancies with RFM (irrespective of outcome) had greater area with signs of infarction (3.5% vs. 0.6%; p

AB - Background: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM. Objective: To determine whether maternal perception of reduced fetal movements (RFM) is associated with abnormalities in placental structure and function. Design: Placentas were collected from women with RFM after 28 weeks gestation if delivery occurred within 1 week. Women with normal movements served as a control group. Placentas were weighed and photographs taken. Microscopic structure was evaluated by immunohistochemical staining and image analysis. System A amino acid transporter activity was measured as a marker of placental function. Placentas from all pregnancies with RFM (irrespective of outcome) had greater area with signs of infarction (3.5% vs. 0.6%; p

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KW - Adult

KW - Amino Acid Transport System A/metabolism

KW - Female

KW - Fetal Growth Retardation/etiology

KW - Fetal Movement

KW - Humans

KW - Infant, Newborn

KW - Infant, Small for Gestational Age

KW - Perception

KW - Placenta/blood supply/pathology/physiopathology

KW - Pregnancy

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DO - 10.1371/journal.pone.0034851

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VL - 7

JO - PLoS ONE

JF - PLoS ONE

IS - 4

M1 - e34851

ER -

Maternal perception of reduced fetal movements is associated with altered placental structure and function

Abstract

Keywords

UN SDGs

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Impacts

Preventing Stillbirth and Improving the Quality of Care After a Baby Dies

Cite this