Abstract
Clinical Question
Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children?
Bottom Line statement
Certain antiepileptic drugs were associated with increased rates of congenital malformations (e.g. spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.9% in 2565 pregnancies) in comparison to the offspring of women without epilepsy (2.51% in 2154 pregnancies).
Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children?
Bottom Line statement
Certain antiepileptic drugs were associated with increased rates of congenital malformations (e.g. spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.9% in 2565 pregnancies) in comparison to the offspring of women without epilepsy (2.51% in 2154 pregnancies).
| Original language | English |
|---|---|
| Pages (from-to) | 1700-1701 |
| Journal | JAMA: The Journal of the American Medical Association |
| Volume | 318 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 7 Nov 2017 |