Maternal use of antiepileptic agents during pregnancy and major congenital malformations in children

Rebecca Bromley, Anthony G Marson, Jennifer Weston

Research output: Contribution to journalArticlepeer-review

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Abstract

Clinical Question
Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children?
Bottom Line statement
Certain antiepileptic drugs were associated with increased rates of congenital malformations (e.g. spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.9% in 2565 pregnancies) in comparison to the offspring of women without epilepsy (2.51% in 2154 pregnancies).
Original languageEnglish
Pages (from-to)1700-1701
JournalJAMA: The Journal of the American Medical Association
Volume318
Issue number17
DOIs
Publication statusPublished - 7 Nov 2017

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