Mathematical modelling of the response of tumour cells to radiotherapy

N.F. Kirkby, N.G. Burnet, D.B.F. Faraday

Research output: Contribution to journalArticlepeer-review


Using a model of cell cycle (CelCyMUS) in which the cell population is described in terms of the cell age and position within the cell cycle typical radiotherapy strategies are simulated, and the effects compared to clinical results, showing reasonable qualitative agreement. Alternative strategies are tested on a slow and a fast-growing tumour and the strategy most likely to completely destroy the tumour is found to depend on the growth rate. This work may have important applications for the development of novel radiotherapy fractionation, for example, schedules to take advantage of hypersensitivity to small doses of radiation exhibited by some tumours, which might improve results compared to conventional dosing strategies.
Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalNuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Issue number1-4
Publication statusPublished - 2002


  • Cancer
  • Radiotherapy
  • Mathematical model
  • Cell cycle


Dive into the research topics of 'Mathematical modelling of the response of tumour cells to radiotherapy'. Together they form a unique fingerprint.

Cite this