Matrix Loading: Assembly of Extracellular Matrix Collagen Fibrils during Embryogenesis

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    Nothing in biology stimulates the imagination like the development of a single fertilized egg into a newborn child. Consequently, a major focus of biomedical research is aimed at understanding cell differentiation, proliferation, and specialization during child health and human development. However, the fact that the increase in size and shape of the growing embryo has as much to do with the extracellular matrix (ECM) as with the cells themselves, is largely overlooked. Cells in developing tissues are surrounded by a fiber-composite ECM that transmits mechanical stimuli, maintains the shape of developing tissues, and functions as a scaffold for cell migration and attachment. The major structural element of the ECM is the collagen fibril. The fibrils, which are indeterminate in length, are arranged in different tissues in exquisite supramolecular architectures, including parallel bundles, orthogonal lamellae, and concentric weaves. This article reviews our current understanding of the synthesis and assembly of collagen fibrils, and discusses challenging questions about how cells assemble an organized ECM during embryogenesis. © 2004 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)1-11
    Number of pages10
    JournalBirth Defects Research Part C - Embryo Today: Reviews
    Issue number1
    Publication statusPublished - Mar 2004


    • Collagen fibrils
    • Embryogenesis
    • Extracellular matrix
    • Procollagens


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