Measurement of radiation dose to the thyroid using positron emission tomography

R. J. Ott; V. Batty; S. Webb; M. A. Flower; M. O. Leach; R. Clack; P. K. Marsden; V. R. McCready; J. E. Bateman; H. Sharma

Measurement of radiation dose to the thyroid using positron emission tomography

R. J. Ott, V. Batty, S. Webb, M. A. Flower, M. O. Leach, R. Clack, P. K. Marsden, V. R. McCready, J. E. Bateman, H. Sharma

Research output: Contribution to journal › Article › peer-review

Abstract

Measurements of the functioning volume of thyroid tissue have been made in 22 patients undergoing radioiodine therapy for thyrotoxicosis, using a prototype multiwire proportional counter positron camera. Tomographic images were produced of the distribution of 124I in the thyroid. Functioning volumes were found to be in the range 21-79 cm3 with volume errors of the order of ± 4% to ± 14%. Radioiodine uptake varied from 28% to 98%. Using a value of 6 days for the effective half-life of radioiodine in hyperactive thyroids, radiation doses from a standard therapy administration of 75 MBq of 131I varied from 11 to 48 Gy (compared with a recommended 50-70 Gy). In five cases PET imaging showed a non-uniform distribution of radioiodine in thyroids thought to have uniform uptake from conventional pinhole scintigraphy.

Original language	English
Pages (from-to)	245-251
Number of pages	6
Journal	British Journal of Radiology
Volume	60
Issue number	711
Publication status	Published - 1987

Cite this

@article{fee9e66c2a114946905d27cc4a7539af,

title = "Measurement of radiation dose to the thyroid using positron emission tomography",

abstract = "Measurements of the functioning volume of thyroid tissue have been made in 22 patients undergoing radioiodine therapy for thyrotoxicosis, using a prototype multiwire proportional counter positron camera. Tomographic images were produced of the distribution of 124I in the thyroid. Functioning volumes were found to be in the range 21-79 cm3 with volume errors of the order of ± 4% to ± 14%. Radioiodine uptake varied from 28% to 98%. Using a value of 6 days for the effective half-life of radioiodine in hyperactive thyroids, radiation doses from a standard therapy administration of 75 MBq of 131I varied from 11 to 48 Gy (compared with a recommended 50-70 Gy). In five cases PET imaging showed a non-uniform distribution of radioiodine in thyroids thought to have uniform uptake from conventional pinhole scintigraphy.",

author = "Ott, {R. J.} and V. Batty and S. Webb and Flower, {M. A.} and Leach, {M. O.} and R. Clack and Marsden, {P. K.} and McCready, {V. R.} and Bateman, {J. E.} and H. Sharma",

year = "1987",

language = "English",

volume = "60",

pages = "245--251",

journal = "British Journal of Radiology",

issn = "1748-880X",

publisher = "British Institute of Radiology",

number = "711",

}

TY - JOUR

T1 - Measurement of radiation dose to the thyroid using positron emission tomography

AU - Ott, R. J.

AU - Batty, V.

AU - Webb, S.

AU - Flower, M. A.

AU - Leach, M. O.

AU - Clack, R.

AU - Marsden, P. K.

AU - McCready, V. R.

AU - Bateman, J. E.

AU - Sharma, H.

PY - 1987

Y1 - 1987

N2 - Measurements of the functioning volume of thyroid tissue have been made in 22 patients undergoing radioiodine therapy for thyrotoxicosis, using a prototype multiwire proportional counter positron camera. Tomographic images were produced of the distribution of 124I in the thyroid. Functioning volumes were found to be in the range 21-79 cm3 with volume errors of the order of ± 4% to ± 14%. Radioiodine uptake varied from 28% to 98%. Using a value of 6 days for the effective half-life of radioiodine in hyperactive thyroids, radiation doses from a standard therapy administration of 75 MBq of 131I varied from 11 to 48 Gy (compared with a recommended 50-70 Gy). In five cases PET imaging showed a non-uniform distribution of radioiodine in thyroids thought to have uniform uptake from conventional pinhole scintigraphy.

AB - Measurements of the functioning volume of thyroid tissue have been made in 22 patients undergoing radioiodine therapy for thyrotoxicosis, using a prototype multiwire proportional counter positron camera. Tomographic images were produced of the distribution of 124I in the thyroid. Functioning volumes were found to be in the range 21-79 cm3 with volume errors of the order of ± 4% to ± 14%. Radioiodine uptake varied from 28% to 98%. Using a value of 6 days for the effective half-life of radioiodine in hyperactive thyroids, radiation doses from a standard therapy administration of 75 MBq of 131I varied from 11 to 48 Gy (compared with a recommended 50-70 Gy). In five cases PET imaging showed a non-uniform distribution of radioiodine in thyroids thought to have uniform uptake from conventional pinhole scintigraphy.

M3 - Article

SN - 1748-880X

VL - 60

SP - 245

EP - 251

JO - British Journal of Radiology

JF - British Journal of Radiology

IS - 711

ER -

Measurement of radiation dose to the thyroid using positron emission tomography

Abstract

Fingerprint

Cite this