Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects

David Buckley, David L. Buckley, Ala'a E. Shurrab, Ching M. Cheung, Andrew P. Jones, Hari Mamtora, Philip A. Kalra

    Research output: Contribution to journalArticlepeer-review


    Purpose: To compare two methods for assessing the single kidney glomerular filtration rate (SK-GFR) in humans using dynamic contrast-enhanced (DCE)-MRI. Materials and Methods: Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland-Patlak plot and a compartmental model. MR estimates of the SK-GFR were compared with standard radioisotope measures in a total of 75 kidneys. Results: Estimates of renal function using both techniques correlated well with radioisotope-assessed SK-GFR (Spearman's ρ = 0.81, Rutland-Patlak; ρ = 0.71, compartmental model). The Rutland-Patlak approach provided a near one-to-one correspondence, while the compartmental method tended to overestimate SK-GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland-Patlak approach. Conclusion: DCE-MRI of the kidneys provides data that correlate well with reference measures of SK-GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. © 2006 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)1117-1123
    Number of pages6
    JournalJournal of Magnetic Resonance Imaging
    Issue number5
    Publication statusPublished - Nov 2006


    • Gadolinium
    • Glomerular filtration
    • Kidney
    • Perfusion
    • Renovascular disease
    • Tracer kinetics


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