Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

Thomas Dever, Terri Goss Kinzy, Graham D Pavitt

    Research output: Contribution to journalArticlepeer-review


    In this review, we provide an overview of protein synthesis in the yeast Saccharomyces cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other eukaryotes, and molecular genetic studies in budding yeast have provided critical insights into the fundamental process of translation as well as its regulation. The review focuses on the initiation and elongation phases of protein synthesis with descriptions of the roles of translation initiation and elongation factors that assist the ribosome in binding the messenger RNA (mRNA), selecting the start codon, and synthesizing the polypeptide. We also examine mechanisms of translational control highlighting the mRNA cap-binding proteins and the regulation of GCN4 and CPA1 mRNAs.
    Original languageEnglish
    Pages (from-to)65-107
    Number of pages43
    Issue number1
    Publication statusPublished - 1 May 2016


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