Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs

John E. Hyde

doi:10.1016/S1286-4579(01)01524-6

Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs

John E. Hyde

Research output: Contribution to journal › Article › peer-review

Abstract

Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.

Original language	English
Pages (from-to)	165-174
Number of pages	9
Journal	Microbes and Infection
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S1286-4579(01)01524-6
Publication status	Published - 2002

Keywords

Antifolates
Artemisinin
Atovaquone
Chloroquine
Halofantrine
Mefloquine
Quinine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1286-4579(01)01524-6

Cite this

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abstract = "Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here. {\textcopyright} 2002 {\'E}ditions scientifiques et m{\'e}dicales Elsevier SAS. All rights reserved.",

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AU - Hyde, John E.

PY - 2002

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AB - Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.

KW - Antifolates

KW - Artemisinin

KW - Atovaquone

KW - Chloroquine

KW - Halofantrine

KW - Mefloquine

KW - Quinine

U2 - 10.1016/S1286-4579(01)01524-6

DO - 10.1016/S1286-4579(01)01524-6

M3 - Article

C2 - 11880048

SN - 1286-4579

VL - 4

SP - 165

EP - 174

JO - Microbes and Infection

JF - Microbes and Infection

IS - 2

ER -

Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs

Abstract

Keywords

UN SDGs

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