Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs

John E. Hyde

    Research output: Contribution to journalArticlepeer-review


    Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
    Original languageEnglish
    Pages (from-to)165-174
    Number of pages9
    JournalMicrobes and Infection
    Issue number2
    Publication statusPublished - 2002


    • Antifolates
    • Artemisinin
    • Atovaquone
    • Chloroquine
    • Halofantrine
    • Mefloquine
    • Quinine


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