Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates

Jae Won Shin, Joe Swift, Irena Ivanovska, Kyle R. Spinler, Amnon Buxboim, Dennis E. Discher

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Adult stem cells and progenitors are of great interest for their clinical application as well as their potential to reveal deep sensitivities to microenvironmental factors. The bone marrow is a niche for at least two types of stem cells, and the prototype is the hematopoietic stem cell/progenitors (HSC/Ps), which have saved many thousands of patients for several decades now. In bone marrow, HSC/Ps interact functionally with marrow stromal cells that are often referred to as mesenchymal stem cells (MSCs) or derivatives thereof. Myosin and matrix elasticity greatly affect MSC function, and these mechanobiological factors are now being explored with HSC/Ps both in vitro and in vivo. Also emerging is a role for the nucleus as a mechanically sensitive organelle that is semi-permeable to transcription factors which are modified for nuclear entry by cytoplasmic mechanobiological pathways. Since therapies envisioned with induced pluripotent stem cells and embryonic stem cells generally involve in vitro commitment to an adult stem cell or progenitor, a very deep understanding of stem cell mechanobiology is essential to progress with these multi-potent cells. © 2013 International Society of Differentiation.
    Original languageEnglish
    Pages (from-to)77-86
    Number of pages9
    JournalDifferentiation
    Volume86
    Issue number3
    DOIs
    Publication statusPublished - Oct 2013

    Keywords

    • Hematopoiesis
    • Matrix
    • Mechanobiology
    • Myosin
    • Nucleus

    Fingerprint

    Dive into the research topics of 'Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates'. Together they form a unique fingerprint.

    Cite this