Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma

A M Jordan; T H Khan; H M Osborn; A Photiou; P A Riley

Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma

A M Jordan, T H Khan, H M Osborn, A Photiou, P A Riley

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired manner. Furthermore, differential cytotoxicity has been demonstrated in cell lines which express tyrosinase and those which do not.

Original language	English
Pages (from-to)	1775-80
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	7
Issue number	9
Publication status	Published - Sept 1999

Keywords

Animals
CHO Cells
Cricetinae
Magnetic Resonance Spectroscopy
Melanocytes
Melanoma
Monophenol Monooxygenase
Prodrugs
Tumor Cells, Cultured

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma",

abstract = "A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired manner. Furthermore, differential cytotoxicity has been demonstrated in cell lines which express tyrosinase and those which do not.",

keywords = "Animals, CHO Cells, Cricetinae, Magnetic Resonance Spectroscopy, Melanocytes, Melanoma, Monophenol Monooxygenase, Prodrugs, Tumor Cells, Cultured",

author = "Jordan, \{A M\} and Khan, \{T H\} and Osborn, \{H M\} and A Photiou and Riley, \{P A\}",

year = "1999",

month = sep,

language = "English",

volume = "7",

pages = "1775--80",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Melanocyte-directed enzyme prodrug therapy (MDEPT)

T2 - development of a targeted treatment for malignant melanoma

AU - Jordan, A M

AU - Khan, T H

AU - Osborn, H M

AU - Photiou, A

AU - Riley, P A

PY - 1999/9

Y1 - 1999/9

N2 - A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired manner. Furthermore, differential cytotoxicity has been demonstrated in cell lines which express tyrosinase and those which do not.

AB - A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired manner. Furthermore, differential cytotoxicity has been demonstrated in cell lines which express tyrosinase and those which do not.

KW - Animals

KW - CHO Cells

KW - Cricetinae

KW - Magnetic Resonance Spectroscopy

KW - Melanocytes

KW - Melanoma

KW - Monophenol Monooxygenase

KW - Prodrugs

KW - Tumor Cells, Cultured

M3 - Article

C2 - 10530924

SN - 0968-0896

VL - 7

SP - 1775

EP - 1780

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 9

ER -

Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma

Abstract

Keywords

UN SDGs

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