Melanoma biology and new targeted therapy

Vanessa Gray-Schopfer; Claudia Wellbrock; Richard Marais

doi:10.1038/nature05661

Melanoma biology and new targeted therapy

Vanessa Gray-Schopfer, Claudia Wellbrock, Richard Marais

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Melanoma is a cancer that arises from melanocytes, specialized pigmented cells that are found predominantly in the skin. The incidence of melanoma is rising steadily in western populations - the number of cases worldwide has doubled in the past 20 years. In its early stages malignant melanoma can be cured by surgical resection, but once it has progressed to the metastatic stage it is extremely difficult to treat and does not respond to current therapies. Recent discoveries in cell signalling have provided greater understanding of the biology that underlies melanoma, and these advances are being exploited to provide targeted drugs and new therapeutic approaches.

Original language	English
Pages (from-to)	851-857
Number of pages	6
Journal	Nature
Volume	445
Issue number	7130
DOIs	https://doi.org/10.1038/nature05661
Publication status	Published - 22 Feb 2007

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nature05661

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abstract = "Melanoma is a cancer that arises from melanocytes, specialized pigmented cells that are found predominantly in the skin. The incidence of melanoma is rising steadily in western populations - the number of cases worldwide has doubled in the past 20 years. In its early stages malignant melanoma can be cured by surgical resection, but once it has progressed to the metastatic stage it is extremely difficult to treat and does not respond to current therapies. Recent discoveries in cell signalling have provided greater understanding of the biology that underlies melanoma, and these advances are being exploited to provide targeted drugs and new therapeutic approaches.",

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AB - Melanoma is a cancer that arises from melanocytes, specialized pigmented cells that are found predominantly in the skin. The incidence of melanoma is rising steadily in western populations - the number of cases worldwide has doubled in the past 20 years. In its early stages malignant melanoma can be cured by surgical resection, but once it has progressed to the metastatic stage it is extremely difficult to treat and does not respond to current therapies. Recent discoveries in cell signalling have provided greater understanding of the biology that underlies melanoma, and these advances are being exploited to provide targeted drugs and new therapeutic approaches.

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Melanoma biology and new targeted therapy

Abstract

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