Memory effects and Lévy walk dynamics in intracellular transport of cargoes

Sergei Fedotov, Nickolay Korabel, Thomas Waigh, Daniel Han, Victoria Allan

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We demonstrate the phenomenon of cumulative inertia in intracellular transport involving multiple motor proteins in human epithelial cells by measuring the empirical survival probability of cargoes on the microtubule and their detachment rates. We found the longer a cargo moves along a microtubule, the less likely it detaches from it. As a result, the movement of cargoes is non-Markovian and involves a memory. We observe memory effects on the scale of up to 2 s. We provide a theoretical link between the measured detachment rate and the superdiffusive Lévy-walk-like cargo movement.
Original languageEnglish
JournalPhysical Review E: covering statistical, nonlinear, biological, and soft matter physics
Early online date22 Oct 2018
Publication statusPublished - 2018

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