Messages in the Matrix: Proteoglycans Go the Distance

John Gallagher

Messages in the Matrix: Proteoglycans Go the Distance

John Gallagher

Research output: Contribution to journal › Article › peer-review

Abstract

The fibroblast growth factors (FGFs) are key regulators of cell growth and differentiation during embryogenesis. They deliver both short-range and distant signals assisted by their proteoglycan (PG) coreceptors in the pericellular matrix. The study by Hou et al. (2007) has identified a novel autoinductive loop involving FGF and the secreted serine protease xHtrA1 that leads to the mobilization of latent FGF/PG complexes. These complexes are long-range messages for mesoderm induction and establishment of the embryonic body plan. © 2007 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	166-167
Number of pages	1
Journal	Developmental cell
Volume	13
Issue number	2
Publication status	Published - 7 Aug 2007

Cite this

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title = "Messages in the Matrix: Proteoglycans Go the Distance",

abstract = "The fibroblast growth factors (FGFs) are key regulators of cell growth and differentiation during embryogenesis. They deliver both short-range and distant signals assisted by their proteoglycan (PG) coreceptors in the pericellular matrix. The study by Hou et al. (2007) has identified a novel autoinductive loop involving FGF and the secreted serine protease xHtrA1 that leads to the mobilization of latent FGF/PG complexes. These complexes are long-range messages for mesoderm induction and establishment of the embryonic body plan. {\textcopyright} 2007 Elsevier Inc. All rights reserved.",

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AB - The fibroblast growth factors (FGFs) are key regulators of cell growth and differentiation during embryogenesis. They deliver both short-range and distant signals assisted by their proteoglycan (PG) coreceptors in the pericellular matrix. The study by Hou et al. (2007) has identified a novel autoinductive loop involving FGF and the secreted serine protease xHtrA1 that leads to the mobilization of latent FGF/PG complexes. These complexes are long-range messages for mesoderm induction and establishment of the embryonic body plan. © 2007 Elsevier Inc. All rights reserved.

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SN - 1878-1551

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JO - Developmental cell

JF - Developmental cell

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Messages in the Matrix: Proteoglycans Go the Distance

Abstract

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